| Name | Character | Episodes |
|---|---|---|
| Anthony Fauci | Self (archive footage) | 2 |
| Bill Gates | Self | 2 |
| J.K. Simmons | Self - Narrator | 1 |
| Idris Elba | Self - Narrator | 1 |
| Donald Trump | Self (archive footage) | 1 |
| Laura Linney | Self - Narrator | 1 |
| Anderson Cooper | Self (archive footage) | 1 |
| Justin Trudeau | Self (archive footage) | 1 |
| Mike Pence | Self (archive footage) | 1 |
| Narendra Modi | Self (archive footage) | 1 |
| Jair Bolsonaro | Self (archive footage) | 1 |
| Boris Johnson | Self (archive footage) | 1 |
| Andrew Cuomo | Self (archive footage) | 1 |