| Name | Character | Episodes |
|---|---|---|
| Jackie Gleason | Chester A. Riley | 26 |
| Rosemary DeCamp | Peg Riley | 26 |
| Bob Jellison | Waldo Binny | 26 |
| Jimmy Lydon | 2 | |
| Paul Bryar | Policeman | 1 |
| Harry Harvey | Doctor H. Harvey | 1 |
| Alan Reed | 1 | |
| Alan Reed | Ferguson | 1 |
| Emory Parnell | Clay J. Stevenson | 1 |
| Tito Vuolo | 1 | |
| Harry Lauter | 1 | |
| Sid Tomack | Jim Gillis | 1 |
| Sid Tomack | Gillis | 1 |
| Marie Blake | Hospital Nurse | 1 |
| Queenie Leonard | 1 | |
| Mary Treen | Millie - Stevenson's Secretary | 1 |