| Cruz Manuelos, a rough-around-the-edges but passionate young Marine, is recruited to join the CIA's Lioness Engagement Team to help bring down a terrorist organization from within. Joe, the station chief of the Lioness program, is tasked with training, managing and leading her female undercover operatives. |
| Name | Character | Episodes |
|---|---|---|
| Zoe Saldaña | Joe McNamara | 16 |
| Nicole Kidman | Kaitlyn Meade | 16 |
| Hannah Love Lanier | Kate McNamara | 16 |
| Jill Wagner | Bobby | 16 |
| Laysla De Oliveira | Cruz Manuelos | 16 |
| Dave Annable | Neal McNamara | 16 |
| Austin Hébert | Randy | 16 |
| James Jordan | Two Cups | 16 |
| LaMonica Garrett | Tucker | 16 |
| Jonah Wharton | Tex | 16 |
| Thad Luckinbill | Kyle McManus | 14 |
| Michael Kelly | Byron Westfield | 14 |
| Morgan Freeman | Secretary of State Edwin Mullins | 10 |
| Celestina Harris | Charlie | 10 |
| Stephanie Nur | Aaliyah Amrohi | 8 |
| Genesis Rodriguez | Captain Josephina 'Josie' Carrillo | 8 |
| Max Martini | Tracer | 8 |
| Martin Donovan | Errol Meade | 8 |
| Jennifer Ehle | Chief of Staff Mason | 7 |
| Bruce McGill | NSA Advisor Hollar | 7 |
| Kirk Acevedo | Special Agent Gutierrez | 4 |
| Demi Castro | Pablo Carrillo | 4 |
| Jay Huguley | JSOC Commander Dixon | 4 |
| Taylor Sheridan | Cody Spears | 3 |
| Layla Mohammadi | Nashwa | 3 |
| Patricia De Leon | Maria Carrillo | 3 |
| Dawn Olivieri | Amber Whalen | 2 |
| Robyn Lively | Senator Albright | 2 |
| Annabeth Gish | Denise Westfield | 2 |
| Matt Gerald | Cody | 2 |
| Paul Diaz | Agent Alan Marshall | 2 |
| Angelina Boris | Cheerleader #2 | 2 |
| Sam Asghari | Kamal | 2 |
| Fawad Siddiqui | Guard #4 | 2 |
| Mike Heslin | Polo | 2 |
| Matt Consalvo | EMT 3 | 1 |
| Logan Crawford | News Anchor | 1 |
| Graham Shiels | Drill Sergeant | 1 |
| Rob Mayes | Co-Pilot Mike | 1 |
| Lauren Mary Kim | Daiu Suen | 1 |
| America Olivo | Dr. Elsa Ramirez | 1 |
| David Alan Basche | Dr. Brumley | 1 |
| Donny Boaz | Steve Cannon | 1 |
| Michael Park | Dr. Gary Brown | 1 |
| Todd Terry | Ronnie Blackstone | 1 |
| Ana Cruz Kayne | Means | 1 |
| Michelle Lee | Nurse | 1 |
| Clark Carmichael | Senator Palmer | 1 |
| Mustafa Haidari | Suicide Bomber | 1 |
| Zach Appelman | LT. Jennings | 1 |
| Anthony Ruiz | Manager of Tast E Burger | 1 |
| Marcus DeAnda | Alvaro Carrillo | 1 |
| Nicholas Massouh | Surgeon | 1 |
| Chris Wang | NSA Analyst | 1 |
| Stevie Ray Dallimore | Colonel Dirves | 1 |
| Chris Lindsay-Abaire | Dr. Shipley | 1 |
| Samara Gonzalez | Hostess | 1 |
| Maggie Parto | Fariha | 1 |
| Ryan T. Johnson | Aspen's Boyfriend | 1 |
| Abraham Justice | Eyes | 1 |
| Bassem Youssef | Amrohi | 1 |
| Adam Budron | Sami | 1 |
| Cody Easterbrook | Trauma Surgeon | 1 |
| Michele Ammon | Mindels Manager | 1 |
| Daniel Abeles | Captain Hansmuth | 1 |
| Migs Govea | Jimenez | 1 |
| Kevin Sebastian | EMT 2 | 1 |
| Edward Brence | Punk Thief #1 | 1 |
| Johnny Vincent | Medic | 1 |
| Susana Gibb | Anesthesiologist | 1 |
| Sean Avery | SF Operator | 1 |