| Name | Character | Episodes |
|---|---|---|
| Ron Ely | Mike Madison | 32 |
| Keith Larsen | Drake Andrews | 32 |
| Jeremy Slate | Larry Lahr | 32 |
| Charles Bronson | Hector Morrison | 1 |
| James Coburn | Joe Casey | 1 |
| Peter Falk | Jeremiah Wilson | 1 |
| Peter Falk | Angel | 1 |
| Burt Reynolds | Jimmy | 1 |
| Ned Glass | 1 | |
| Telly Savalas | Paul Price | 1 |
| John Fiedler | Mr. Jacobs | 1 |
| Susan Oliver | Laura West | 1 |
| Antoinette Bower | Linda Liggett | 1 |
| Everett Sloane | James Stonehill | 1 |
| Ed Nelson | Chris Garland | 1 |
| Dean Jones | John Anderson | 1 |
| Robert Vaughn | Wes Grayson | 1 |
| Jim Davis | Sam Hogarth | 1 |
| Inger Stevens | Margot Allison | 1 |
| John Marley | Lieutenant | 1 |
| Dyan Cannon | Diana Hogarth | 1 |
| Paul Henreid | Richard Nincel | 1 |
| Brad Dexter | Carney | 1 |
| Mary Tyler Moore | Dana March | 1 |
| Mort Mills | 1 | |
| Pippa Scott | Oga Danylo | 1 |
| Al Ruscio | Ralph D'Amico | 1 |
| Neil Hamilton | Larry La Beau | 1 |
| Barney Phillips | Captain Markle | 1 |
| Lynn Bari | Ann Nincel | 1 |
| Sue Randall | Mimi Newell | 1 |
| Sam Levene | Lieutenant Maharis | 1 |
| John Considine | Chris Curtis | 1 |
| Denver Pyle | Captain Leo Stohl | 1 |
| Keenan Wynn | George Morrisey | 1 |
| Margaret O'Brien | Ellen Marstand | 1 |
| Yvonne Craig | Kathy | 1 |
| John Dierkes | Inspector Crail | 1 |
| Edward Binns | Ed Barron | 1 |
| Alfred Ryder | Nico Kofie | 1 |
| Joe Turkel | Danny | 1 |
| Leo Penn | Moe | 1 |
| Leslie Parrish | Jill Talley | 1 |
| Milton Selzer | Ray Parker | 1 |
| William Conrad | Corey | 1 |
| Robert Strauss | Ben Penfield | 1 |
| Gina Gillespie | Lisa | 1 |
| Richard Carlson | Ross Porter | 1 |
| Whitney Blake | Ruth Cheney | 1 |
| Harry Townes | Robert L. Radcliffe | 1 |
| Larry Pennell | Tyler Stack | 1 |
| Paula Raymond | Judy O'Brien | 1 |
| Russ Conway | Commander | 1 |
| Cecil Parker | Dr. Cattermole | 1 |
| Joyce Meadows | Barbara Nincel | 1 |
| Joyce Meadows | Adrian | 1 |
| Erin O'Brien | Valerie | 1 |
| Frank Albertson | Mr. Linden | 1 |
| Donna Douglas | 1 | |
| Joe Maross | Lieutenant | 1 |
| Pauline Drake | Mrs. Fraser | 1 |
| June Blair | June Noreen | 1 |
| Naura Hayden | Susan Rand | 1 |
| Kaye Elhardt | Nancy Wilson | 1 |
| Diana Millay | Peg Knight | 1 |
| Mike Steen | 1 | |
| Mike Steen | Motorcycle Cop | 1 |
| Patricia Cutts | Christiana Waverly | 1 |
| Leora Dana | Viviam | 1 |
| Valerie Allen | Consuelo | 1 |
| Gerald Mohr | Pete Burdett | 1 |
| Dan Tobin | Lew Finley | 1 |
| Dan Tobin | Danton Spangler | 1 |
| Kent Smith | George | 1 |