| The Secrets of Isis is the syndicated title of a live action CBS television series produced by Filmation in the 1970s originally titled Isis that appeared during the Saturday morning cartoon lineup. The show was also aired in various countries around the world. As indicated on commentary in the 2007 DVD release of the series, and supported by examining broadcast premiere dates, The Secrets of Isis was the first weekly American live-action television series whose lead character was a female superhero, debuting September 6, 1975 and predating the weekly debuts of both The Bionic Woman and Wonder Woman. |
| Name | Character | Episodes |
|---|---|---|
| JoAnna Cameron | Andrea Thomas / Isis | 22 |
| Craig Wasson | Feather | 2 |
| Jerry Douglas | Inspector Bryce | 2 |
| Paul Hampton | The Professor | 2 |
| Ben Frank | Larry | 2 |
| Michael Blodgett | Sam | 2 |
| Colleen Camp | Wynn | 1 |
| Morgan Jones | Mr. Tilden | 1 |
| Barry Miller | Charlie | 1 |
| Lou Frizzell | Chuck Nelson | 1 |
| Steven Paul | Kevin McCauley | 1 |
| Christopher Norris | Dorothy Bieder | 1 |
| Leigh McCloskey | Bill Cady | 1 |
| Mitch Vogel | Wayne Moss | 1 |
| Thomas Carter | Fabian | 1 |
| Laurette Spang | Ann | 1 |
| Philip Bruns | Jack Evans | 1 |
| James Griffith | Dr. Blandford | 1 |
| Mark Lambert | Fred Wieting | 1 |
| Mike Lookinland | Tom Anderson | 1 |
| Evan C. Kim | C.J. Howe(as Evan Kim) | 1 |
| Evan C. Kim | C.J. Howe (as Evan Kim) | 1 |
| Victor Sen Yung | Mr. Chen | 1 |
| Buddy Foster | Billie | 1 |
| Scott Colomby | Lee Webster | 1 |
| Brian Byers | Steve | 1 |
| Kathleen O'Malley | Mrs. Schuster | 1 |
| Anson Downes | Phil Hobbs | 1 |
| Johnny Doran | Randy Martin | 1 |
| Brad David | Steve | 1 |
| William Engesser | Bigfoot | 1 |
| Cynthia Avila | Chela Montoya | 1 |
| Roger Kern | Dave Parkes | 1 |
| Charles Cyphers | Sam Niles | 1 |
| Kelly Thordsen | Joel Moss | 1 |
| Josh Albee | Ernie Rothchild | 1 |