| Ten year old child prodigy, Chiyo Mihama, is finding it tough fitting in at high school with the girls five years her elder: Osaka (dimwitted with a weird take on the world), Tomo (a powder keg that goes off at a moment’s notice), Kagura (the competitive athlete of the bunch), Yomi (the hothead), and Sakaki (timid and obsessed with a love of animals that isn’t reciprocated). Together with their teacher, they navigate the rough waters and fun times of high school. | 
| Name | Character | Episodes | 
|---|---|---|
| Aya Hisakawa | Minamo Kurosawa (voice) | 26 | 
| Yuu Asakawa | Sakaki (voice) | 26 | 
| Rie Tanaka | Koyomi Mizuhara (voice) | 26 | 
| Tomoko Kaneda | Chiyo Mihama (voice) | 26 | 
| Koji Ishii | Kimura (voice) | 15 | 
| Norio Wakamoto | Chiyo-Father (voice) | 4 | 
| Sayaka Ohara | Kimura's Wife (voice) | 2 | 
| Makoto Yasumura | Male Student (voice) | 1 | 
| Makoto Yasumura | Student (voice) | 1 | 
| Koji Ishii | Kimura (Voice) | 0 |