| "There are those among us who can move at will between the world of the wolves and the world of the humans. My people call them skin walkers." Seattle police detective John Kanin has a problem. He's in love, but shortly after agreeing to marry him, his girlfriend disapears. His search leads to her home town, where people are clearly hiding information from him. One of the things they are hiding is the fact that they are all werewolves, as is John's girlfriend, Ruby. |
| Name | Character | Episodes |
|---|---|---|
| Paul Wesley | Luke Cates | 10 |
| Mary Elizabeth Winstead | Sophia Donner | 9 |
| Lou Diamond Phillips | John Kanin | 9 |
| Mia Kirshner | Ruby Cates | 9 |
| Tim Matheson | Sheriff Matthew Donner | 9 |
| Graham Greene | Sherman Blackstone | 9 |
| Carmen Moore | Deputy Molly Bloom | 9 |
| Sharon Lawrence | Vivian Cates | 9 |
| Scott Bairstow | Tyler Creed | 9 |
| Bruce McGill | Willard Cates | 6 |
| Christian Bocher | Buddy Hooks | 6 |
| Kellie Waymire | Miranda Devereaux | 5 |
| Craig Bruhnanski | Malachi | 3 |
| Craig Olejnik | Sean | 2 |
| Steve Zahn | Fletch (uncredited) | 1 |
| Mary Elizabeth Winstead | Sophia Kohanek | 1 |
| Bruce McGill | Dr. Sokolov | 1 |
| Lou Diamond Phillips | Noah Cassidy | 1 |
| Jeff Fahey | Russell Kelly | 1 |
| Tim Matheson | Sheriff Jack Kohanek | 1 |
| Myron Natwick | Vernon | 1 |
| Nathaniel DeVeaux | Lieutenant | 1 |
| Christian Bocher | Buddy Hookes | 1 |
| Campbell Lane | Lyle Bingham | 1 |
| Colleen Wheeler | Duty Nurse | 1 |
| R. Nelson Brown | Old Timer | 1 |
| Suzy Joachim | Hannah | 1 |
| Xander Berkeley | Carl | 1 |
| Ryan Robbins | Fletcher | 1 |
| Austin Nichols | Scott Nichols | 1 |
| Sarah Carter | Brianna | 1 |
| Graham Greene | Professor Duke Joseph | 1 |
| Jodelle Ferland | Lily Kelly | 1 |
| Glynis Davies | Sue Ellis | 1 |
| Françoise Yip | Reporter | 1 |
| Frank C. Turner | Drycleaner Owner | 1 |
| Sam Anderson | Arthur Van Halen | 1 |
| Lauren K. Robek | Marie Donner | 1 |
| Colin Lawrence | Robinson | 1 |
| Gregory Itzin | Gerald Carter | 1 |
| W. Earl Brown | Bruce Cates | 1 |
| Stacy Edwards | Alexandra Kelly | 1 |
| Sarah Lind | Sarah Hollander | 1 |
| Carmen Moore | Deputy Turnbull | 1 |
| Jason Kravits | Bradley | 1 |
| Linden Banks | Dr. Chapman | 1 |
| Scott Heindl | Harvey Rockwell | 1 |
| Kiersten Warren | Nancy | 1 |
| Mark Hildreth | Billy | 1 |
| John Cassini | Eddie | 1 |
| Robert Wisden | Wallace | 1 |
| Julie Patzwald | Lenore | 1 |
| Douglas Arthurs | Diner Owner | 1 |
| Frank Cassini | John | 1 |
| Peter LaCroix | Deputy Yager | 1 |
| Kimberley Warnat | Kit | 1 |
| Will Sanderson | Travis | 1 |
| Tiffani Timms | Young Mother | 1 |
| Tom Pickett | Sheriff Truesdale | 1 |
| Michael Daingerfield | Dale | 1 |
| Mitchell Kosterman | Salters | 1 |
| Dean Paul Gibson | Dr. Jessup | 1 |
| Matthew Currie Holmes | Donald Wrye | 1 |
| Jacqueline Samuda | Jean Hollander | 1 |
| Amber Rothwell | Tammy Holt | 1 |
| Don Ackerman | Unkempt Young Man | 1 |
| Adrienne Carter | Davi Sokolov | 1 |
| John R. Taylor | Don Ritchey | 1 |