| A gifted heart surgeon excels in her new leadership role as Chief of Surgery after her renowned boss falls into a coma. When her former boss wakes up months later demanding to resume his duties, Sam is tasked with supervising this egotistical expert with a scalpel who never acknowledged her stellar talent. |
| Name | Character | Episodes |
|---|---|---|
| Jason Isaacs | Rob Griffith | 13 |
| Wendy Crewson | Vivian Katz | 13 |
| Sophia Bush | Sam Griffith | 13 |
| Edwin Hodge | Malcolm Kingsley | 13 |
| Skye P. Marshall | Lex Trulie | 13 |
| Omar Maskati | Isan Shah | 13 |
| Michael Stahl-David | Caleb Tucker | 13 |
| Davi Santos | Joey Costa | 13 |
| Stephen Tracey | Tim Davis | 9 |
| Marium Carvell | Donna Williams | 2 |
| Hilarie Burton | Gretchen Taylor | 1 |
| Bethany Joy Lenz | Amy Taylor | 1 |
| Patrice Goodman | Monique Jenkins | 1 |
| Milton Barnes | Roman's Dad | 1 |
| David Huband | David Ferguson | 1 |
| Sabryn Rock | Roman's Mom | 1 |
| Samy Osman | Angry Husband | 1 |