| Name | Character | Episodes |
|---|---|---|
| Eleanor David | Sancia | 10 |
| Anne-Louise Lambert | Lucrezia Borgia | 10 |
| Barbara Shelley | Vannozza Canale | 10 |
| Adolfo Celi | Rodrigo Borgia | 10 |
| Clive Merrison | Ascanio Sforza | 10 |
| Peter Benson | Gaspare Pato | 10 |
| Oliver Cotton | Cesare Borgia | 10 |
| Maurice O'Connell | Michelotto | 10 |
| Alfred Burke | Giuliano della Rovere | 10 |
| Nicholas Le Prevost | Baglioni | 10 |
| Ralph Nossek | Johann Burchard | 10 |
| Martin Potter | Paolo Orsini | 10 |