| Name | Character | Episodes |
|---|---|---|
| Leslie Nielsen | Lt. Price Adams | 36 |
| John Beradino | Sgt. Vince Cavelli | 36 |
| Byron Morrow | Capt. Keith Gregory | 36 |
| John Clarke | Off. Joe Huddleston | 36 |
| Victor Jory | Deacon Lee | 2 |
| Strother Martin | Benny Kohler | 2 |
| Ed Begley | Masters | 2 |
| Ivan Dixon | Wick | 2 |
| Charles Bronson | Jerry Bergason | 1 |
| Peter Falk | Lopez | 1 |
| Robert Redford | Arthur Honniger - Hitchhiker | 1 |
| Martin Balsam | Frank Eberhardt | 1 |
| Bryan O'Byrne | Cannon | 1 |
| Hope Summers | Mrs. McCurtin | 1 |
| Burt Brinckerhoff | Willis | 1 |
| Ron Howard | Tommy Simms | 1 |
| Telly Savalas | Dr. Buel Reed | 1 |
| Victor Buono | Manrique | 1 |
| John Fiedler | Perkins | 1 |
| Eddie Albert | Walter Cowley | 1 |
| Peter Fonda | Ronnie Bryson | 1 |
| Tina Louise | Stella Knowland | 1 |
| Anne Francis | Phyllis Eberhardt | 1 |
| William Windom | Warren Giles | 1 |
| Sydney Pollack | Austin Rogers | 1 |
| Sydney Pollack | Bert Masters | 1 |
| Cloris Leachman | Elsie Condon | 1 |
| Virginia Gregg | Georgine | 1 |
| Sherry Jackson | Ellen Talltree | 1 |
| Gloria Grahame | Nurse Nora Springer | 1 |
| Joan Hackett | Angie | 1 |
| Vic Morrow | Belman | 1 |
| James Gregory | Father Al | 1 |
| Ed Nelson | Jefty Bright | 1 |
| Ed Nelson | Roger Sykes | 1 |
| Jack Klugman | Floyd Blaylock | 1 |
| Nehemiah Persoff | Louis Morley | 1 |
| Leif Erickson | Dr. Eric Thor | 1 |
| Paul Richards | Hobbins | 1 |
| Fritz Weaver | Arthur Grissom | 1 |
| Paul Carr | Johnny | 1 |
| Joanne Linville | Grace Kegler | 1 |
| Keir Dullea | Frank | 1 |
| Wendell Corey | Roger Dawson | 1 |
| Don Taylor | Fred Kingman | 1 |
| Eduardo Ciannelli | Tulio Rossi | 1 |
| Barry Morse | Morgan Dolgelly | 1 |
| Barry Morse | Virgil Payne | 1 |
| David Lewis | Maury Keeler | 1 |
| David Lewis | Townsend | 1 |
| Judi Meredith | Florence Charron | 1 |
| James Doohan | Dr. Lennon | 1 |
| Robert Middleton | Stanley Mannis | 1 |
| John Larch | John Clark | 1 |
| Rebecca Welles | 1 | |
| Stanley Adams | Larry Gruber | 1 |
| Natalie Trundy | Inge Halverson | 1 |
| Bea Benaderet | Miss Horne | 1 |
| Charles Aidman | Dr. Ted Reisman | 1 |
| Dina Merrill | Ruth Kingman | 1 |
| Barney Phillips | Sergeant Steiner | 1 |
| Peter Whitney | Matson | 1 |
| John Larkin | Chuck Graffer | 1 |
| Peter Helm | Lennie Rath | 1 |
| Mario Alcalde | Barney Talltree | 1 |
| Mario Alcalde | Frank Danielo | 1 |
| Lynn Bari | Mrs. Grace | 1 |
| Robert Blake | Bobby Madero | 1 |
| Laraine Day | Vivian Cowley | 1 |
| Miriam Colon | Dolores Madero | 1 |
| William Schallert | Gilbert Condon | 1 |
| Keenan Wynn | Ronson | 1 |
| Andrew Prine | Werner Muelich | 1 |
| Margo | Mrs. Madero | 1 |
| Yvonne Craig | Louise Pittman / Edna Pittman | 1 |
| Henry Jones | Davidson | 1 |
| Arlene Martel | Maria Danielo | 1 |
| Gary Merrill | Karl Lippert | 1 |
| Simon Oakland | Felix Pascal | 1 |
| Edward Binns | Crafts | 1 |
| Richard Bakalyan | 1 | |
| Joseph Wiseman | Clayton Grimes | 1 |
| Royal Dano | Harry Tilden | 1 |
| Parley Baer | Pop O'Shea | 1 |
| Vaughn Taylor | Felix Wainwright | 1 |
| Nan Martin | Margaret | 1 |
| Linda Watkins | Wilma Donnelly | 1 |
| Charles McGraw | Dr. Cameron Hill | 1 |
| Les Tremayne | Garland | 1 |
| Milton Selzer | Dr. Harmon | 1 |
| Norman Burton | Poulos | 1 |
| Jeanne Cooper | Helen | 1 |
| Joan Staley | Sophie | 1 |
| Cecil Kellaway | Mr. Weltschmerz | 1 |
| Jack Oakie | Ham Tucker | 1 |
| Michael Constantine | Oscar Holloway | 1 |
| Virginia Field | Iris | 1 |
| Joseph Ruskin | Donnell | 1 |
| Henry Beckman | Sergeant Rayless | 1 |
| Ben Wright | Frank Andrews | 1 |
| Sandra Warner | Sandy Demarest | 1 |
| Sandra Warner | Mrs. Flyer | 1 |
| Edward Andrews | Hutch Hutchins | 1 |
| James Flavin | Moose | 1 |
| Susan Gordon | Muffin Reisman | 1 |
| Kevin Hagen | Arne Halverson | 1 |
| Stafford Repp | Lt. Howard Cline | 1 |
| Eileen Heckart | Harriet Dawson | 1 |
| Paula Raymond | Andrea Beauvoir | 1 |
| Virginia Christine | Annabelle | 1 |
| Arthur O'Connell | Peter Capples | 1 |
| Chris Robinson | Clifford Forbes | 1 |
| Patricia Breslin | Ruth Wollock | 1 |
| Margaret Hayes | Eve Steiner | 1 |
| Nelson Leigh | Dr. Halsted | 1 |
| Betsy Jones-Moreland | Claire Arnet | 1 |
| Phyllis Love | Mrs. Capples | 1 |
| Bartlett Robinson | Victor Kredenza | 1 |
| Bartlett Robinson | Farnum | 1 |
| Barbara Baxley | Eve Lippert | 1 |
| Brett Somers | Dorothy Blaylock | 1 |
| Doro Merande | Miss Stewart | 1 |
| Ralph Taeger | Tad Calloway | 1 |
| Diana Millay | Connie Weems | 1 |
| Iphigenie Castiglioni | Carla Rossi | 1 |
| Ilka Chase | Cynthia Webster | 1 |
| Anita Sands | Sue | 1 |
| Laura Devon | Ann Fetterson | 1 |
| Amanda Randolph | Mattie | 1 |
| Josephine Hutchinson | Nettie | 1 |
| Mike Kellin | Moran | 1 |
| Richard Arlen | Willits | 1 |
| Lin McCarthy | John Kegler | 1 |