| Name | Character | Episodes |
|---|---|---|
| Felicia Day | Codex | 70 |
| Sandeep Parikh | Zaboo | 70 |
| Amy Okuda | Tinkerballa | 70 |
| Jeff Lewis | Vork | 70 |
| Wil Wheaton | Fawkes | 16 |
| Viji Nathan | Zaboo's Mom | 15 |
| Michele Boyd | Riley | 14 |
| Corey Martin Craig | Donovan | 10 |
| J. Teddy Garces | Bruiser | 9 |
| Teal Sherer | Venom | 9 |
| Sujata Day | Sula Morrison | 8 |
| Hayley Holmes | Rachel | 6 |
| Erin Gray | Madeleine Twain | 5 |
| Milynn Sarley | Blue Master Chief | 5 |
| Clare Grant | Red Master Chief | 5 |
| Doug Jones | Gerald | 4 |
| Frank Ashmore | Ollie - Cheesybeard's Boss | 4 |
| Floyd Van Buskirk | John | 4 |
| Tymberlee Hill | Jeanette | 4 |
| Mark Gantt | Chet Grunwald | 3 |
| Annie Sertich | Costume Official | 3 |
| Maurissa Tancharoen | Alina | 3 |
| Grant Imahara | Grant Imahara | 3 |
| Derek Basco | Roy | 3 |
| Nathan Fillion | Nathan Fillion | 2 |
| Brea Grant | Brea Grant | 2 |
| Frank Ashmore | Cheesybeard's Boss | 2 |
| Jillian Armenante | Lizette | 2 |
| Richard Hatch | Richard Hatch | 2 |
| Justine Ezarik | Sabina | 2 |
| Dichen Lachman | Dichen Lachman | 1 |
| Simon Helberg | Kevinator | 1 |
| Eliza Dushku | Eliza Dushku | 1 |
| Zachary Levi | Zachary Levi | 1 |
| Kevin Sorbo | Kevin Sorbo | 1 |
| Brandon Molale | Brandon Molale | 1 |
| Stan Lee | Self | 1 |
| Brent Spiner | Brent Spiner | 1 |
| Rick Fox | Rick Fox | 1 |
| Greg Collins | Greg Collins | 1 |
| Neil Gaiman | Neil Gaiman | 1 |
| Tom Lenk | Tom Lenk | 1 |
| Colin Ferguson | Colin Ferguson | 1 |
| Mark Gantt | Chet Granwald | 1 |
| Rod Keller | Transvestite Hooker | 1 |
| Tom Konkle | Parent | 1 |
| Wilson Cleveland | Gonathan | 1 |
| Rileah Vanderbilt | Princess Leia | 1 |
| Andrew Law | Restaurant patron | 1 |
| Andrew Law | Cheesybeards Patron | 1 |
| Andrew Law | Convention Attendee | 1 |
| Greg Aronowitz | Convention goer | 1 |