| Name | Character | Episodes |
|---|---|---|
| Mike Farrell | Jim Hansen | 96 |
| Melina Kanakaredes | Sydney Hansen | 96 |
| Concetta Tomei | Lynda Hansen | 96 |
| Paula Cale | Joanie Hansen | 96 |
| Seth Peterson | Robbie Hansen | 96 |
| George Newbern | Owen Frank | 21 |
| Alex D. Linz | Pete Calcatera | 21 |
| Jon Hamm | Burt Ridley | 15 |
| Tom Verica | Kyle Moran | 13 |
| Jeffrey Nordling | Dr. David Baylor | 10 |
| Angela Featherstone | Andi Paulsen | 9 |
| Scott Thompson | Elliot Anderman | 9 |
| Denis Arndt | Dr. Bill Augustine | 8 |
| Marcia Strassman | Meredith | 8 |
| Tom Cavanagh | Doug Boyce | 7 |
| Nicki Aycox | Lily Gallagher | 7 |
| Rob Estes | John Hemming | 7 |
| Cristine Rose | Cynthia Blake | 7 |
| Steven Eckholdt | Congressman Joe Connelly | 6 |
| Josh Daugherty | Charlie Abbott | 6 |
| Eric Bruskotter | Richie | 5 |
| Ed Begley Jr. | Chuck Chance | 5 |
| Stacy Galina | Allison Hoffman | 5 |
| Nicole Paggi | Britney | 5 |
| Patrick Fabian | Jerry Kaufman | 4 |
| Alyson Reed | Lenore Decker | 4 |
| Donald Sage Mackay | Officer Duncan | 4 |
| Lindsay Crouse | Lauren MacKenzie | 4 |
| Alastair Duncan | Graham Hollings | 4 |
| Jim Pirri | Peter Calcatera | 4 |
| Michael Reilly Burke | Brady Pullman | 4 |
| Lori Rom | Danielle | 4 |
| Ashley Johnson | Daphne Wallace | 3 |
| Emily Bergl | 3 | |
| Victoria Principal | Donna Tupperman | 3 |
| Tippi Hedren | Constance Hemming | 3 |
| Matt Letscher | Kevin Norris | 3 |
| John Bennett Perry | Charles Frank | 3 |
| Jay Acovone | Vincent | 3 |
| Joe Spano | Dr. Carroll | 3 |
| Joe Flanigan | Dr. David Marcus | 3 |
| Leonard Roberts | 3 | |
| Mary Page Keller | Monica Lang | 3 |
| Connie Ray | Hazel | 3 |
| Ernie Sabella | Lou Keppler | 3 |
| Kelly Perine | Reggie | 3 |
| Mike Kelley | Kelly | 3 |
| David Lee Smith | Paul Rutigliata | 3 |
| Mae Whitman | Frances Carlyle | 2 |
| Debi Mazar | Vonda Vickers | 2 |
| Emily Deschanel | Annie Frank | 2 |
| Patrick Fabian | Jerry | 2 |
| Markus Flanagan | Bruce Larson | 2 |
| Calvin Jung | 2 | |
| Time Winters | Father | 2 |
| Michael Landes | Tom Cromwell | 2 |
| Sally Kellerman | Nora Frank | 2 |
| Katherine Helmond | Rose Bidwell | 2 |
| Jim Lau | Anchee's Father | 2 |
| Marilu Henner | Georgia | 2 |
| Chad Donella | Kevin's Imaginary Friend | 2 |
| Kyle Howard | Aidan Green | 2 |
| Heidi Swedberg | 2 | |
| Stephen Caffrey | Father Bell | 2 |
| Anne Haney | Mary Aliperti | 2 |
| Constance Zimmer | Megan | 2 |
| Joseph Mazzello | Tony | 2 |
| Mark L. Taylor | Ted Miller | 2 |
| David Marciano | George | 2 |
| Allison Smith | Lynn Fischer | 2 |
| Bob Morrisey | 2 | |
| Rick Roberts | Dr. Hopper | 2 |
| John Fugelsang | Mr. Chris Calloway | 2 |
| David Dunard | Police Chief | 2 |
| Bette Ford | Hildy | 2 |
| Rick Scarry | Cooking Teacher | 2 |
| Joseph Whipp | Shelter Employee | 2 |
| Frank Birney | 2 | |
| John Harrington Bland | Rental Car Clerk | 2 |
| Frank Santorelli | Sal | 2 |
| Lea Moreno Young | Kathy Evans | 2 |
| Rachel Quaintance | Susan Murray | 2 |
| David Stenstrom | Cop | 2 |
| Annette Helde | Dr. Jordan | 2 |
| Tania Raymonde | Alice / Young Syd | 1 |
| Howie Mandel | Self (uncredited) | 1 |
| Amy Adams | Rebecca 'Becka' Taylor | 1 |
| Lauren Holly | Darla Rosario | 1 |
| Jon Hamm | Burt Ridley / Zorro | 1 |
| Viola Davis | Dr. Eleanor Weiss | 1 |
| Michael McKean | Sherman Smith | 1 |
| Julie Ann Emery | Winnie | 1 |
| JoAnna Garcia Swisher | Gillian | 1 |
| Kurt Fuller | Michael | 1 |
| Kurt Fuller | Thrifty Ticket Agent | 1 |
| Laz Alonso | Eddie | 1 |
| Alanna Ubach | Darla Owens | 1 |
| Rick Hoffman | Benji Brickman | 1 |
| Tamlyn Tomita | Mary Cassidy | 1 |
| Nick Chinlund | Daniel Hartman | 1 |
| Bug Hall | Jackie | 1 |
| P.J. Marino | Jonny | 1 |
| Jason Sklar | Dan | 1 |
| Kevin Otto | Jack Hudson | 1 |
| Kristine Sutherland | Joyce Moore | 1 |
| Renée Humphrey | Dana Maguire | 1 |
| Rachel Winfree | Focus Group Lady #2 | 1 |
| Rachel Winfree | Clarissa | 1 |
| Jack Coleman | Larry | 1 |
| Holmes Osborne | Marcus Weber | 1 |
| Leslie Silva | Dr. Helen Reynolds | 1 |
| Time Winters | Minister | 1 |
| Gregory Jbara | Drew | 1 |
| Melissa Rivers | Self | 1 |
| Morgan Fairchild | Gwendolynne Gold | 1 |
| Robert Pine | Congressman | 1 |
| Kathryn Morris | Molly | 1 |
| James Roday Rodriguez | Alexander Conrad | 1 |
| Ann Dowd | Mary | 1 |
| Thad Luckinbill | Jack Finch | 1 |
| Glenn Morshower | Mr. McDonnell | 1 |
| Molly Hagan | Mrs. Trish Calloway | 1 |
| Dan Lauria | John Currier | 1 |
| Larry Miller | Dr. Minkus | 1 |
| Martin Starr | 1 | |
| John Getz | Dr. Sullivan | 1 |
| Beth Grant | Lillian Gerrish | 1 |
| Barry Shabaka Henley | 1 | |
| Jay Leno | Lucky the Dog (voice) | 1 |
| Derek Webster | 1 | |
| Steve Valentine | The Mad Hatter | 1 |
| William Windom | Harold Joyce | 1 |
| Rosemary Forsyth | Elaine | 1 |
| Constance Towers | Candice Whitman / Cromwell | 1 |
| Susan Walters | Kerry King | 1 |
| David Rasche | Doc Croc | 1 |
| Tamara Taylor | Tracy Doyle | 1 |
| Elaine Kagan | Card Player #3 | 1 |
| Gabrielle Fitzpatrick | Victoria Everdeen | 1 |
| Ethan Phillips | Finch | 1 |
| Richard Riehle | Simon, Inspector | 1 |
| Alfonso Freeman | JAG Prosecutor | 1 |
| Dante Basco | Justin Kim | 1 |
| Edie McClurg | Meryl Ridley | 1 |
| Diane Franklin | Diane Cavalero | 1 |
| David Henrie | Mark Triedman | 1 |
| Charles Esten | Ted Shannon | 1 |
| Allison Mack | Alicia | 1 |
| Johnny Whitworth | Jason Zeller | 1 |
| Brad William Henke | Luke English | 1 |
| David Sutcliffe | Russell Banks | 1 |
| Nancy Lenehan | Jane | 1 |
| Peter Jason | Frank Moore | 1 |
| Robert Costanzo | Carlo | 1 |
| Michael B. Silver | Ken | 1 |
| Bruce French | Goat Mascot Raider | 1 |
| Judith Hoag | Susan Marcus | 1 |
| Lou Wagner | Weird Job Applicant | 1 |
| Kathleen Freeman | Miss Van Gundy | 1 |
| Kirsten Nelson | Kim | 1 |
| Joseph D. Reitman | Radio Station Manager | 1 |
| Todd Stashwick | Vic | 1 |
| Henry Gibson | Mr. Berry | 1 |
| Denis Arndt | 1 | |
| Ross Bagley | Eldon | 1 |
| Steven Culp | Dr. Jordan Roberts | 1 |
| Tessa Allen | Hannah Hansen | 1 |
| Gina Hecht | 1 | |
| Mickey Jones | 1 | |
| Richard Burgi | Dr. J.D. Scanlon | 1 |
| Lawrence Pressman | Dr. Clemens | 1 |
| Michael Des Barres | Yule | 1 |
| Jerry Levine | Dan Freed | 1 |
| Wendy Schaal | Nancy Neiman | 1 |
| Mark Moses | 1 | |
| Glenn Shadix | 1 | |
| Barry Primus | Gordon | 1 |
| Eric Stonestreet | Ted Stout | 1 |
| Tony Jay | 1 | |
| Hal Ozsan | Rolando | 1 |
| Kevin Cooney | Hospital Doctor | 1 |
| Danny Woodburn | Barnabus Finkel | 1 |
| Debbi Morgan | Marilyn Chase | 1 |
| Sam Lloyd | Mr. Smith | 1 |
| Eileen Ryan | Eleanor Walters | 1 |
| Skye McCole Bartusiak | Jessie | 1 |
| Dion Anderson | Lester Moody | 1 |
| Michelle Phillips | Blair Mason | 1 |
| Paul Dooley | Bill Ridley | 1 |
| James Sie | Delivery Guy | 1 |
| Chase Ellison | Jake | 1 |
| Michael Dempsey | Mr. Conlon | 1 |
| Michael Dempsey | 1 | |
| Sal Viscuso | 1 | |
| Susan Yeagley | Student #1 | 1 |
| John Marshall Jones | Richard Zaks | 1 |
| Rhyon Nicole Brown | Fiona | 1 |
| Bryan Greenberg | Neal | 1 |
| Robert Gant | Dancing groom | 1 |
| Estelle Harris | Darlene | 1 |
| Alix Elias | Mrs. Blanchard | 1 |
| Joyce Guy | Dr. Peterson's Secretary | 1 |
| Bobby Edner | Edward 'Eddie' Joyce | 1 |
| Cliff Bemis | Mr. Mallory | 1 |
| Katherine Ann McGregor | Restaurant Manager | 1 |
| Melissa Gilbert | Lorna Berlin | 1 |
| Peter Onorati | Mike O'Brien | 1 |
| Betty White | Julianna | 1 |
| Jay Acovone | Aldini | 1 |
| Barbara Alyn Woods | Heidi | 1 |
| Jack McGee | 1 | |
| Josef Sommer | Thomas Wheelock | 1 |
| Cynthia Ettinger | Sylvia Rohan | 1 |
| Steve Eastin | 1 | |
| Henri Lubatti | 1 | |
| Brian Tarantina | 1 | |
| Diane Delano | B.J. Maximus | 1 |
| Sean O'Bryan | Dr. Rick Rozelli | 1 |
| Jennifer Crystal Foley | Krista | 1 |
| Michael Ensign | 1 | |
| Meredith Scott Lynn | Debbie | 1 |
| Bodhi Elfman | Suspicious Guy | 1 |
| Michelle Krusiec | Dong-Lu | 1 |
| Laura Harrington | Gina Vinton | 1 |
| Geoffrey Rivas | 1 | |
| Amy Farrington | Liza Gruber | 1 |
| Troy Evans | Cooking Contest Prize Announcer | 1 |
| Julianne Christie | 1 | |
| Troy Evans | Freddie Devilla | 1 |
| Josh Coxx | Patrick | 1 |
| Rachel True | Talia Weber | 1 |
| Kate McNeil | Randi | 1 |
| Aloma Wright | Orderly | 1 |
| Ellen Bry | Lorraine | 1 |
| Silvana Gallardo | Marta | 1 |
| Victoria Tennant | Dr. Toynton | 1 |
| Mika Boorem | Zoe | 1 |
| Steven Flynn | 1 | |
| Harrison Young | Monroe Ellison | 1 |
| Connor Matheus | Redneck Jr. | 1 |
| Paul Eiding | Hank | 1 |
| John Durbin | Shopkeeper | 1 |
| Shoshannah Stern | Renee | 1 |
| Susan Gibney | 1 | |
| Louis Giambalvo | Clown | 1 |
| John Cothran | 1 | |
| Nancy Stephens | Dr. Blake | 1 |
| Kelly Jo Minter | 1 | |
| Mimi Paley | Kylie | 1 |
| Jan Hooks | Doreen Dunfey | 1 |
| Brad Grunberg | Flowers Delivery Leader | 1 |
| Annie O'Donnell | Mrs. Mayfield | 1 |
| Kelsey Mulrooney | Tracy Barrows | 1 |
| Christina Vidal | Street Girl | 1 |
| Lee Weaver | 1 | |
| Cory Tyler | Customer #1 | 1 |
| Rusty Schwimmer | Ms. Polly Maravich | 1 |
| Carmine Giovinazzo | Kit | 1 |
| Bonnie Burroughs | Mom | 1 |
| Jana Marie Hupp | Karen Potter | 1 |
| John Capodice | Carl Rutigliata | 1 |
| Phil Abrams | Mr. Edwards | 1 |
| Jackie Flynn | College Student | 1 |
| Tom McCleister | 1 | |
| Harvey J. Alperin | Salesman | 1 |
| Peggy McCay | Dorothy Chenoweth | 1 |
| Bill Macy | Mr. Foley | 1 |
| Kaitlin Hopkins | 1 | |
| Shashawnee Hall | Det. Hawthorne | 1 |
| Catlin Adams | Rebecca Rosen | 1 |
| Scarlett Pomers | Becky | 1 |
| Mary Gross | Martha Blankenship | 1 |
| Robin Gammell | 1 | |
| Marcia Wallace | Gelinda | 1 |
| Tony Scott | Young Kerry | 1 |
| Miriam Flynn | Mrs. Hartford | 1 |
| John Fugelsang | 1 | |
| Ryan Francis | Carson | 1 |
| Marian Mercer | Card Player #2 | 1 |
| Frederick Coffin | Steven Zeller | 1 |
| Shelley Berman | 1 | |
| Nancy Dussault | Sylvia Anderman | 1 |
| Hope Allen | Lips Patient | 1 |
| Renee Olstead | Little Girl | 1 |
| Andrea Bendewald | Elizabeth Jannaur | 1 |
| Jim Turner | Andy Boyer | 1 |
| Gail Strickland | Evelyn Lombard | 1 |
| Michael Winters | Dr. Anthony | 1 |
| Peter Siragusa | 1 | |
| Matthew Ashford | Mr. Henderson | 1 |
| Jon Wellner | Van Buyer | 1 |
| Michael Fairman | Frank Gerrish | 1 |
| Susan Krebs | Woman Neighbor | 1 |
| Lise Simms | Shelly | 1 |
| Jason Stuart | Stage Manager | 1 |
| Wendy Braun | Kate | 1 |
| Perry Anzilotti | Dr. Curtis | 1 |
| Skip Stellrecht | Policeman | 1 |
| Rachelle Carson | Jill | 1 |
| Fran Bennett | Chairwoman | 1 |
| Amy Castle | Lisa | 1 |
| Roger Hewlett | Paramedic | 1 |
| Bradford Tatum | Doug Kosowsky | 1 |
| Charles Keating | St. Peter | 1 |
| Austin Majors | Son | 1 |
| Tina Morasco | 1 | |
| Jesse Corti | Lt. Morris | 1 |
| Doug McGrath | Impatient #2 | 1 |
| Kirk Trutner | Dr. Weisenstock | 1 |
| Stacy Barnhisel | Mrs. Parker | 1 |
| Tony Papenfuss | Cowboy | 1 |
| Anthony Holiday | Fireman | 1 |
| Jordan Lund | Rick | 1 |
| Erik Audé | Jason | 1 |
| Beverly Sanders | 1 | |
| Michael Milhoan | Mr. Babbington | 1 |
| Rick Zieff | 1 | |
| Deborah Strang | Elizabeth Gurwyn | 1 |
| Ryan Alosio | Jake | 1 |
| Kitty Swink | Nurse | 1 |
| Monty Hall | Pageant Emcee | 1 |
| Michael McLafferty | Cute Guy | 1 |
| Carol Potter | Karen Ashworth | 1 |
| John D. LeMay | Resident #2 | 1 |
| Thom Gossom Jr. | Albert Clemmons | 1 |
| Arturo Gil | White Rabbit | 1 |
| Heidi Mark | 1 | |
| Jeremy Glazer | Chad | 1 |
| Chao Li Chi | Tao | 1 |
| Jason Hall | Stewart | 1 |
| Linda Carlson | Talk Show Host | 1 |
| Kenneth Moskow | Salesman | 1 |
| Dave Buzzotta | 1 | |
| Christina Carlisi | 1 | |
| Randy Sklar | Jack | 1 |
| Roger Lodge | Self | 1 |
| Joseph Hacker | 1 | |
| Amy Warner | Doctor #1 | 1 |
| Bruce Thomas | Beau Tucker | 1 |
| Fab Filippo | Marcello | 1 |
| Cecil Hoffman | Nancy Jenners | 1 |
| Robert Floyd | Male Stripper Wally | 1 |
| John F. O'Donohue | Henry Pillup | 1 |
| Rodney Van Johnson | T.C. Russell | 1 |
| Gretchen Wyler | Angie | 1 |
| Emmett Shoemaker | 1 | |
| Magda Harout | Mrs. Kolchek | 1 |
| Magda Harout | Card Dealer | 1 |
| Bryan Hearne | Craig Barnett | 1 |
| Kathryn Joosten | Miss O'Meara | 1 |
| Kathryn Joosten | Mrs. Nielsen | 1 |
| Jim Hanna | Man | 1 |
| Richard Romanus | Dr. Paul Gavins | 1 |
| Anjul Nigam | Raji | 1 |
| Mary Kathleen Gordon | Nurse | 1 |
| Stephanie Faracy | Nancy Moore | 1 |
| Ann Walker | Judge's Wife | 1 |
| Tristine Skyler | Amy Asher | 1 |