| When emergencies occur, the trauma team from San Francisco City Hospital is first on the scene, traveling by land, by sea or by air to reach their victims in time. From the heights of the city's Transamerica Pyramid to the depths of the San Francisco Bay, these heroes must face the most extreme conditions to save lives, and give meaning to their own existence in the process. |
| Name | Character | Episodes |
|---|---|---|
| Aimee Garcia | Nancy Carnahan | 18 |
| Taylor Kinney | EMT Tyler Briggs | 18 |
| Kevin Rankin | EMT Tyler Briggs | 18 |
| Cliff Curtis | Reuben 'Rabbit' Palchuck | 18 |
| Derek Luke | Cameron Boone | 18 |
| Anastasia Griffith | Nancy Carnahan | 18 |
| Jamey Sheridan | Dr. Joe Saviano | 18 |
| Carl Marino | Karl Sly | 18 |
| Adrian Bustamante | EMT - Paramedic - Brandon Trimmer | 18 |
| Scottie Thompson | 15 | |
| John Terry | 3 | |
| Rosalind Chao | Therapist | 2 |
| Matt Barr | 2 | |
| Taylor Nichols | 1 | |
| Matthew Del Negro | 1 | |
| Stuart Wilson | 1 | |
| Joel Brooks | 1 | |
| Brad Leland | 1 | |
| Chad Faust | 1 | |
| Enuka Okuma | 1 | |
| William Sanderson | 1 | |
| Gene Davis | 1 | |
| Larry Sullivan | 1 | |
| Joseph McFadden | 1 | |
| Mickey River | Todd | 1 |
| Laurence Leboeuf | 0 | |
| Pascale Montpetit | 0 | |
| Catherine de Léan | 0 | |
| Gilbert Sicotte | 0 | |
| Stéphane Demers | 0 |