| Three Rivers is an American television medical drama that debuted on CBS on October 4, 2009, starring Alex O'Loughlin in the role of an infamous transplant surgeon in Pittsburgh, Pennsylvania. On November 30, 2009, after just eight episodes of the season had aired, CBS announced that Three Rivers had been pulled from their schedule with no plans to have it returned, and the series was later officially cancelled. However, the series later returned to the network on June 5, 2010 to burn off the remaining unaired episodes. |
| Name | Character | Episodes |
|---|---|---|
| Alfre Woodard | Dr. Sophia Jordan | 13 |
| Justina Machado | Pam Acosta | 13 |
| Daniel Henney | Dr. David Lee | 13 |
| Alex O'Loughlin | Dr. Andy Yablonski | 13 |
| Katherine Moennig | Dr. Miranda Foster | 13 |
| Mercedes Mason | Vanessa | 4 |
| Rizwan Manji | Dr. Dev | 3 |
| William Sadler | 2 | |
| Kelly Overton | Det. Rena Yablonski | 2 |
| Britt Robertson | Brenda Stark | 1 |
| Joelle Carter | 1 | |
| Alyssa Diaz | 1 | |
| Pablo Schreiber | 1 | |
| Marina Sirtis | 1 | |
| Tessa Thompson | 1 | |
| Mandy Patinkin | 1 | |
| Matt Roth | 1 | |
| Cody Longo | Blair | 1 |
| Michael Gaston | 1 | |
| Michael Mosley | 1 | |
| Sprague Grayden | 1 | |
| Felicia Day | 1 | |
| Nicholas Braun | Michael | 1 |
| Janina Gavankar | 1 | |
| Shiloh Fernandez | 1 | |
| Kevin Rahm | 1 | |
| Arjay Smith | 1 | |
| Brett Cullen | 1 | |
| Lorraine Toussaint | 1 | |
| Lennie James | 1 | |
| Devon Werkheiser | Bobby | 1 |
| Mandy June Turpin | Dr. Sharon Wright (uncredited) | 1 |
| Mac Brandt | 1 | |
| Hillary Tuck | 1 | |
| P.J. Byrne | 1 | |
| Tim Guinee | 1 | |
| James DuMont | 1 | |
| Mekenna Melvin | Angela | 1 |
| Bernard White | 1 | |
| D. C. Douglas | 1 | |
| Paul Perri | 1 | |
| J. Paul Boehmer | 1 | |
| Jermaine Williams | 1 | |
| B.J. Britt | 1 | |
| J. Downing | 1 |