| Name | Character | Episodes |
|---|---|---|
| Sarah Michelle Gellar | Teenage Jacqueline Bouvier | 3 |
| William Devane | Black Jack Bouvier | 3 |
| Rosemary Murphy | Rose Kennedy | 3 |
| Jessica Tuck | Lorraine Murrey | 3 |
| Andy Buckley | John Fitzgerald Kennedy Jr. | 3 |
| Stephen Collins | John Fitzgerald Kennedy | 3 |
| Lisa Eichhorn | Dr. Jordan | 3 |
| Tim Ransom | Robert Kennedy | 3 |
| Ralph Cosham | Dr. Wilson | 3 |
| Bob Gunton | Hugh Auchincloss | 3 |
| Anna Thomson | Ilona | 3 |
| Josef Sommer | Joseph Kennedy Sr. | 3 |
| Roma Downey | Jacqueline Bouvier | 3 |
| Eve Gordon | Marilyn Monroe | 3 |
| Kathleen McNenny | Ethel Kennedy | 3 |
| Boyd Gaines | Yusha Auchincloss | 3 |
| Nick Gregory | Clay Holmby | 3 |
| Stephen Pearlman | City Editor | 3 |
| Kate Skinner | Woman Reporter | 3 |
| Ashley Crow | Lee Bouvier Radziwill | 3 |
| Wendy Hughes | Janet Lee Bouvier | 3 |
| Mark Metcalf | George Smathers | 2 |
| Clark Gregg | Ken O'Donnell | 2 |
| Nan Martin | Diana Vreeland | 2 |
| Nadia Dajani | Christina Onassis | 2 |
| Nancy Youngblut | Press Secretary | 2 |
| Carlin Glynn | Lady Bird Johnson | 2 |
| Brian Smiar | Lyndon B. Johnson | 2 |
| Gary Wade Morton | N Street Photographer | 2 |
| Joss Ackland | Aristotle Onassis | 1 |