| Name | Character | Episodes |
|---|---|---|
| Peter Krause | Casey McCall | 45 |
| Josh Charles | Dan Rydell | 45 |
| Felicity Huffman | Dana Whitaker | 45 |
| Robert Guillaume | Isaac Jaffe | 45 |
| Joshua Malina | Jeremy Goodwin | 45 |
| Greg Baker | Elliott | 45 |
| Sabrina Lloyd | Natalie Hurley | 45 |
| Kayla Blake | Kim | 45 |
| Ted McGinley | Gordon | 8 |
| Teri Polo | 7 | |
| Brenda Strong | 7 | |
| William H. Macy | 6 | |
| Timothy Davis-Reed | Chris | 5 |
| Ron Ostrow | Will | 5 |
| Paula Marshall | 3 | |
| Robert Mailhouse | J.J. | 3 |
| Lisa Edelstein | 2 | |
| Megan Ward | 2 | |
| Tim DeKay | 2 | |
| Clark Gregg | 2 | |
| Alicia Coppola | 1 | |
| Alanna Ubach | 1 | |
| John de Lancie | 1 | |
| Derek Webster | 1 | |
| Ray Wise | Evans | 1 |
| Peter Riegert | 1 | |
| Tom Cavanagh | 1 | |
| Yeardley Smith | Malory Moss | 1 |
| Brad William Henke | Christian Patrick | 1 |
| David Graf | Chase | 1 |
| Felton Perry | 1 | |
| Spencer Garrett | 1 | |
| Janel Moloney | 1 | |
| Nina Siemaszko | 1 | |
| Charlie Finn | 1 | |
| Meredith Vieira | 1 | |
| Eric Bruskotter | 1 | |
| Nina Barry | Claire | 1 |
| Aaron Lustig | Gilbert | 1 |
| Star Jones | 1 | |
| A. Russell Andrews | 1 | |
| Debbie Matenopoulos | 1 | |
| Bernard Hocke | Dave | 1 |