| Name | Character | Episodes |
|---|---|---|
| Wendy Craig | Matron | 87 |
| Denis Lill | Mr. Rose | 87 |
| Amy Robbins | Dr. Jill Weatherill | 87 |
| Robert Daws | Dr. Gordon Ormerod | 87 |
| Linda Armstrong | Sister Brigid | 87 |
| Michael Starke | Ken Hopkirk | 64 |
| Natalie Anderson | Nurse Stella Davenport | 35 |
| Robert Cavanah | Adam Carnegie | 34 |
| Ian Carmichael | T.J. Middleditch | 31 |
| Anna Madeley | Nurse Samantha Beaumont | 20 |
| Gareth Hale | Jack Bell | 18 |
| Amelia Curtis | Nurse Catherine Deane | 16 |
| Julian Ovenden | Dr. David Cheriton | 15 |
| Damian O'Hare | Dr. Nick Burnett | 12 |
| Glynis Barber | Jean McAteer | 12 |
| Polly Maberly | Dr. Lucy Klein | 12 |
| Bill Maynard | Claude Greengrass | 7 |
| Lauren Drummond | Student Nurse Faye Clark | 7 |
| William Simons | PC Alf Ventress | 6 |
| Chris Coghill | Bobby Sheridan | 6 |
| Tony Maudsley | Jimmy Beatie | 4 |
| Tom Mannion | Teddy Catchpole | 4 |
| Lisa Dwyer Hogg | Moira Kilgannon | 4 |
| Honor Blackman | Mrs. Lyons | 3 |
| Matthew McNulty | Stan | 3 |
| Michael Jayston | Henry Appleton | 3 |
| Elizabeth Spriggs | Dolly Smith | 2 |
| Sorcha Cusack | Sinead Donahue | 2 |
| Freddie Jones | Sebastian Fox-Kirby | 2 |
| Tony Haygarth | Father John | 2 |
| Gerard Horan | Ned Worsley | 2 |
| David Lonsdale | David Stockwell | 2 |
| Richard Johnson | Johnny Lomax | 2 |
| Francis Matthews | Dr. James Alway | 2 |
| Berwick Kaler | Eric Fogle | 2 |
| Daragh O'Malley | Niall Donahue | 2 |
| Susan Hampshire | Elizabeth Middleditch | 2 |
| Tricia Penrose | Gina Ward | 2 |
| Jacqueline Boatswain | Safi | 2 |
| Mark Cameron | Billy Yates | 2 |
| Sean McKenzie | Terry Hopkirk | 2 |
| Phyllis Logan | Lady George Fawcett | 1 |
| Siobhan Finneran | Rita Hogg | 1 |
| Holliday Grainger | Carole Green | 1 |
| Matthew Beard | Peter Blackwood | 1 |
| Gabrielle Drake | Margo Price | 1 |
| Keith Clifford | Walter Bannister | 1 |
| Anna Brewster | Cynthia Grant | 1 |
| Tenniel Evans | Mr. Silverwood | 1 |
| Paul Brooke | Dr. Marsden | 1 |
| Trevor Peacock | Grandad | 1 |
| Charles De'Ath | Simon Wake-Palmer | 1 |
| Ben Miller | Shane Brampton | 1 |
| Graham McTavish | Anthony Poole | 1 |
| Martin Compston | Jeffrey Carpenter | 1 |
| James Faulkner | Sir Charles | 1 |
| Prunella Scales | Red Admiral | 1 |
| Shaun Dooley | Martin Tomlinson | 1 |
| Barbara Marten | Assistant Matron Thelma Parker | 1 |
| Daniel Casey | David Hibbert | 1 |
| Rachel Davies | Monkford | 1 |
| Brian Blessed | Sir Edward Fawcett | 1 |
| Jeff Rawle | Banks | 1 |
| Judy Cornwell | Martha Hooke | 1 |
| Francis Magee | Alex Heath | 1 |
| Katherine Kelly | Tina Binnington | 1 |
| Paul Copley | Nesbitt | 1 |
| Maggie O'Neill | Jane Cooper | 1 |
| Phyllida Law | Daisy Crannagh | 1 |
| Tom Georgeson | Duncan Crosby | 1 |
| Derek Fowlds | Oscar Blaketon | 1 |
| James Greene | Dermot Sheahan | 1 |
| Hazel Douglas | Sybil Roper | 1 |
| Naomi Radcliffe | Ella Hale | 1 |
| Guy Burnet | Lenny Lomax | 1 |
| Sian Breckin | Judith Ure | 1 |
| Hayley Tamaddon | Rosie | 1 |
| Samantha Power | Hazel Barton | 1 |
| Jim Norton | Rory | 1 |
| Richard Ridings | Malcolm Hogg | 1 |
| Kevin Doyle | Ralph Fleming | 1 |
| Julia Swift | Mrs. Blackwood | 1 |
| Kenneth Colley | Bernard Hussey | 1 |
| Tony Pitts | Alec Glazer | 1 |
| Sally Ann Matthews | Ellen Dannini | 1 |
| Stephen Bent | Brian Tompkins | 1 |
| Frances Tomelty | Rosemary Briggs | 1 |
| Daniel Ryan | Ray Piper | 1 |
| Richard Johnson | 1 | |
| Sheridan Smith | Francesca Smith | 1 |
| Caroline O'Neill | Ruth Thake | 1 |
| Antony Byrne | Mr. Howarth | 1 |
| Jack Deam | Sam | 1 |
| Christian Cooke | Bobby Horrocks | 1 |
| Lisa Millett | Daniella Galliani | 1 |
| Catherine Tyldesley | Sheila Blunt | 1 |
| Peter Benson | Bernie Scripps | 1 |
| Terence Harvey | Anthony | 1 |
| Andrew Ellis | Jonno | 1 |
| Brittany Ashworth | Siobhan O'Grady | 1 |
| Christopher Villiers | Frank Wellborn | 1 |
| Rosalind Ayres | Grace Parmitter | 1 |
| Samuel Barnett | Joe Steeples | 1 |
| Raymond Pickard | Michael Westerlley | 1 |
| Tristan Sturrock | Charles Dodds | 1 |
| Tim Wylton | Fred Jenkins | 1 |
| Malcolm Raeburn | Patterson | 1 |
| Terrence Hardiman | Dr. Sedgewick | 1 |
| Stephen Moore | Howard Price | 1 |
| John Bowe | Max Freeman | 1 |
| George Irving | Terence Mavers | 1 |
| Lauren Drummond | Student Nurse Fay Clark | 1 |
| Eileen Davies | Mrs. Molly Lynson | 1 |
| Christopher Rozycki | Russian Captain | 1 |
| Rebecca Atkinson | Suzannne | 1 |
| Colin Wells | Duncan Fuller | 1 |
| Philip Martin Brown | Thomas Copley | 1 |
| Jenny Funnell | Anna Freeman | 1 |
| Tracie Bennett | Sylvia | 1 |
| Rita May | Aunt Mary Graham | 1 |
| Jimmy Akingbola | Corporal Frederick Collins | 1 |
| Seamus O'Neill | Mr. Norman Baker | 1 |
| Seamus O'Neill | Len Edwards | 1 |
| Sean Chapman | Carl | 1 |
| Vincenzo Nicoli | Tony Dannini | 1 |
| Benjamin Whitrow | Professor Farrow | 1 |
| Adam Fogerty | Bernie | 1 |
| Rosemary Leach | Hester Hindmarch | 1 |
| Freda Dowie | Dora Rigby | 1 |
| Duncan Preston | John Rutter | 1 |
| Michael Hodgson | Alistair Whenby | 1 |
| Dave Hill | Joey Dudlow | 1 |
| Steve Evets | Lester Marsh | 1 |
| Sydney Wade | Laura | 1 |
| Kenneth Cope | Albert Trent | 1 |
| Tony Britton | 1 | |
| Tony Britton | George Guthrie | 1 |
| John Lightbody | Barry Price | 1 |
| Steve Money | Mr. Bowman | 1 |
| Emma Lowndes | Penny Darnby | 1 |
| Georgia Taylor | Ellen | 1 |
| Serge Soric | George Romain | 1 |
| George Costigan | Hugh Etheridge | 1 |
| Mary Jo Randle | Fay Wallace | 1 |
| Tony Slattery | Phil Granger | 1 |
| Judy Flynn | Lesley Pinner | 1 |
| Gary Whelan | Dr. Arthur Clarkson | 1 |
| Rebecca Johnson | Venetia Wake-Palmer | 1 |
| Angela Thorne | Dorothy Bryant | 1 |
| Robert Lawrenson | Tony Salter | 1 |
| Sacha Parkinson | Polly Crunshank | 1 |
| Marshall Lancaster | Matty | 1 |
| Emma Stansfield | Chrissy | 1 |
| Geoffrey Wilkinson | Caretaker | 1 |
| Sharon Duce | Norma Smithson | 1 |
| Amy Morgan | Julie Woolton | 1 |
| Frank Mills | Mr. Calder | 1 |
| Jane How | Gloria | 1 |
| Tim Dantay | Morrison | 1 |
| Chris Gascoyne | Brian Harris | 1 |
| Olwen May | Sheila | 1 |
| William Travis | Gary Jackman | 1 |
| Paul Popplewell | Chris Nugent | 1 |
| Paul Popplewell | Marlon Barratt | 1 |
| Jane Gurnett | Maggie Harcourt | 1 |
| Philip Bird | Brian Pinner | 1 |
| Cathy Sara | Denise Lambert | 1 |
| Morris Perry | Colonel Bradshaw | 1 |
| Gwyneth Powell | Bunty Weatherill | 1 |
| Jan Harvey | Mrs. Annette Cheriton | 1 |
| Tom Hudson | Walter Metcalf | 1 |
| Derrick O'Connor | Patrick Maver | 1 |
| Angela Lonsdale | Anna Whenby | 1 |
| Peter Gunn | Harry | 1 |
| Niall O'Brien | Father Carroll | 1 |
| James Doherty | Philip Sutton | 1 |
| Katy Cavanagh | Carol Buxton | 1 |
| James Baxter | Simon Watts | 1 |
| Rachel Warren | Estelle | 1 |
| Katherine Dow Blyton | Andrea Bennett | 1 |
| Michael Begley | Patrick Barrie | 1 |
| Jasper Britton | 1 | |
| Jasper Britton | Paul Guthrie | 1 |
| Jo-Anne Stockham | Sister Assumpta | 1 |
| Steve Garti | Andy | 1 |
| Steve Garti | Harold Bardon | 1 |
| Alan David | Mr. Forbes | 1 |
| Ann Rye | Lady Firminger | 1 |
| Alice Barry | Patient | 1 |
| Bobby Ball | John Wilson | 1 |
| Geoffrey Hutchings | Arthur Cordell | 1 |
| Simon Hepworth | David Wilkinson | 1 |
| Robert Blythe | Eric Darnby | 1 |
| John Lloyd Fillingham | Robert Harries | 1 |
| Roger Morlidge | Geoff Bennett | 1 |
| Jane Lowe | Mrs. Smythe | 1 |
| Chiké Okonkwo | Jermaine Johnson | 1 |
| Andrew Dunn | Billy Taylor | 1 |
| Bernard Wrigley | Albert | 1 |
| Abena Ayivor | Alele | 1 |
| Ted Robbins | Ted Skinner | 1 |
| Elizabeth Rider | Miss Wilkinson | 1 |
| Myfanwy Waring | Jessica | 1 |
| David Fleeshman | Don Waite | 1 |
| Sue Jenkins | Mother Peter | 1 |
| Fiona Bruce | Mrs. Rutter | 1 |
| Paul Opacic | Gideon Bradley | 1 |
| Sue Devaney | Daisy Douglas | 1 |
| Matthew Steer | Paul Harman | 1 |
| Annie Hulley | Dolly | 1 |
| Charlie Hardwick | Maggie Thomas | 1 |
| Sean McKenzie | Cliff | 1 |
| Andonis Anthony | Brian Esterleigh | 1 |
| Janine Birkett | Mrs. Troughton | 1 |
| Dennis Blanch | Mr. Chambers | 1 |
| Tony Monroe | Stan | 1 |
| Bernard Gallagher | Alf Wilkinson | 1 |
| Will Tacey | Philip Plumley | 1 |
| Peter Armitage | Bill Smithson | 1 |
| Marie Critchley | Agnes Corbett | 1 |
| Kelly Wenham | Anna | 1 |
| Ryan Hawley | Phil Cooper | 1 |
| Stuart McGugan | Ken Letham | 1 |
| Caroline Carver | Eve Peterson | 1 |
| Craig Cheetham | Graf Spee | 1 |
| Sheree Murphy | Tanya Willson | 1 |
| Ken Bradshaw | Reg Statham | 1 |
| Jeni Howarth Williams | Sheila Willis | 1 |
| Samuel Kane | Rick | 1 |
| Christopher Wright | Richard Fletcher | 1 |
| Karl Haynes | Eddie Frampton | 1 |
| Kate Rutter | Mrs. Baker | 1 |
| Alwyne Taylor | Diane Plumley | 1 |
| Tony Mooney | Stan | 1 |
| Bill Rodgers | Harry | 1 |
| Tara Moran | Helen Gardener | 1 |
| John Branwell | Ray Archer | 1 |
| Jorden Bennie | Jason Hodges | 1 |
| Billy Mack | Liam O'Brien | 1 |
| Bob Mason | Bill Cooper | 1 |
| Elaine Glover | Shirley Bennett | 1 |
| June Broughton | Elsa Jones | 1 |
| Judy Hawkins | Miss Prosser | 1 |
| James Quinn | Peter Turner | 1 |
| Lisa Howard | Jane Tillotson | 1 |
| Basienka Blake | Briony Wellborn | 1 |
| Lorraine Cheshire | Mrs. Hastings | 1 |
| June Whitfield | Esme | 1 |
| Keith Marsh | Ernest | 1 |
| Thelma Barlow | Ada | 1 |
| Madeleine Moffat | Mary Dooley | 1 |
| Adam Allfrey | Mr. Smith | 1 |
| Rachel Mitchem | Pam Fuller | 1 |
| Lee Battle | Stan Sanderson | 1 |
| Madlena Nedeva | Maria Dannini | 1 |
| Andrew Westfield | Captain | 1 |
| Nicky Evans | Eddie Spears | 1 |
| Alison Burrows | Mrs. Thomas | 1 |
| Glynis Barber | 0 | |
| Amelia Curtis | 0 | |
| Robert Cavanah | 0 | |
| Lauren Drummond | 0 | |
| Gareth Hale | 0 | |
| Sydney Wade | 0 | |
| Natalie Anderson | 0 | |
| Polly Maberly | 0 |