| Name | Character | Episodes |
|---|---|---|
| Shane Bourne | Bill 'Happy' Henderson | 56 |
| Angus Grant | Dr. Jamie Lawless | 56 |
| Petra Yared | Layla Young | 56 |
| Jason Donovan | Richard Savage | 44 |
| Angie Milliken | Amanda McKay | 34 |
| Kerry Armstrong | Dr. Louella Davis | 32 |
| Alice McConnell | Caitlin King | 31 |
| Michael Carman | Mark Matthews | 29 |
| Aaron Pedersen | Dr. Tony McKinnon | 23 |
| Lisa McCune | Dr. Liz Gibson | 4 |
| Erik Thomson | David Simpson | 4 |
| Sullivan Stapleton | Ben Quilty | 2 |
| Robert Grubb | Dr. Andrew Gallin | 1 |
| Anthony Hayes | Michael Ross | 1 |
| Jacek Koman | Dr. Mikhail Varonio | 1 |
| Bernard Curry | Troy Dalmer | 1 |
| Ron Falk | Harry Higgins | 1 |
| Asher Keddie | Rachel O'Connor | 1 |
| Belinda Bromilow | Sally Delaney | 1 |
| Tracy Mann | Penny Silvani | 1 |
| Colette Mann | Daphne Lowe | 1 |
| Tina Bursill | Dr. Ruth McIntyre | 1 |
| Val Lehman | Rita O'Reilly | 1 |
| Jude Beaumont | Julie Harper | 1 |
| Rod Mullinar | Dr. Nathan Tate | 1 |
| Alex Papps | Dr. Hamish McGregor | 1 |