| Name | Character | Episodes |
|---|---|---|
| Tilda Swinton | Water | 6 |
| Natasha Lyonne | Suzanna | 6 |
| Joe Rumrill | Bibo (voice) | 6 |
| Julio Torres | Julio Torres / Pirulinpinpina | 6 |
| Bowen Yang | Dodo | 3 |
| Sandra Caldwell | Lawyer | 3 |
| Dylan O'Brien | Dustin | 2 |
| Jaboukie Young-White | Skyler | 2 |
| Ana Fabrega | Trish | 2 |
| Rick Crom | Lawyer | 2 |
| Emma Stone | Genevieve | 1 |
| Tilda Swinton | Water (voice) | 1 |
| Paul Dano | Jeff | 1 |
| Alexa Demie | Becca | 1 |
| Steve Buscemi | Q | 1 |
| Rosie Perez | Bianca | 1 |
| Amy Sedaris | Vanesja's Former Acting Coach | 1 |
| Kate Berlant | Theme Park Madame Victorious | 1 |
| Julia Fox | Mrs. Claus | 1 |
| Sunita Mani | Nancy | 1 |
| Rachel Dratch | Rellany | 1 |
| Maddie Corman | 90 second Clinic Doctor | 1 |
| Aidy Bryant | Denise | 1 |
| John Early | Chips/Figero | 1 |
| Cole Escola | Dina | 1 |
| Bobbi Salvör Menuez | X | 1 |
| Patti Harrison | Fish | 1 |
| Tommy Dorfman | Commercial Director | 1 |
| Evan Mock | Z | 1 |
| Dominique Jackson | Algorithm | 1 |
| Sandy Honig | Dr. Sarah | 1 |
| Matt Barats | Waiter | 1 |
| Josh Sharp | Coco (voice) | 1 |