| Name | Character | Episodes |
|---|---|---|
| James Arness | Zeb Macahan | 28 |
| William Kirby Cullen | Josh Macahan | 28 |
| Bruce Boxleitner | Luke Macahan | 28 |
| Vicki Schreck | Jessie Macahan | 28 |
| Fionnula Flanagan | Molly Culhane | 25 |
| Warren Vanders | Brant | 5 |
| Harris Yulin | Deek Peasley | 4 |
| Eva Marie Saint | Kate Macahan | 3 |
| Lloyd Bridges | Orville Gant | 3 |
| Don Murray | Anderson | 3 |
| Anthony Zerbe | Martin Grey | 3 |
| Biff McGuire | Ed Walters | 3 |
| Eric Braeden | Francis Britten | 3 |
| William Conrad | Narrator (voice) (uncredited) | 3 |
| Peggy McCay | Maggie Taylor | 3 |
| Tim Matheson | Curt Grayson | 2 |
| John Dehner | Bishop Benjamin | 2 |
| Mills Watson | Felix | 2 |
| Brian Keith | General Stonecipher | 2 |
| Paul Fix | Portagee | 2 |
| Jean Allison | Mrs. Stillman | 2 |
| Jack Elam | Cully Madigan | 2 |
| Read Morgan | Lem | 2 |
| James Stephens | C.L. Bradley | 2 |
| Alvy Moore | Swenson | 2 |
| Robert Donner | Mr. Evans | 2 |
| Van Williams | Captain MacAllister | 2 |
| Wilford Brimley | 1 | |
| Wilford Brimley | Sheriff Daniels | 1 |
| Christopher Lee | The Grand Duke | 1 |
| William Shatner | Captain Harrison | 1 |
| Rosalind Chao | Li Sin | 1 |
| Ken Curtis | 1 | |
| Ken Curtis | Orville Gant | 1 |
| Katy Kurtzman | 1 | |
| Kip Niven | Lt. Ayeless | 1 |
| Belinda Montgomery | Florrie | 1 |
| Richard Kiley | Timothy Macahan | 1 |
| Mills Watson | Hutch | 1 |
| L.Q. Jones | Batlin | 1 |
| G.W. Bailey | Ivie | 1 |
| Beverly Garland | Hanna | 1 |
| Richard Moll | Mose | 1 |
| Fernando Lamas | Fierro | 1 |
| Richard Basehart | Colonel Flint | 1 |
| Richard Kelton | Clay Hollingsworth | 1 |
| Dub Taylor | Moss | 1 |
| John Doucette | Sheriff Boland | 1 |
| Ramon Bieri | General Sheridan | 1 |
| John Quade | 1 | |
| Mel Ferrer | Hale Burton | 1 |
| Michael Conrad | Marshal Russell | 1 |
| Michael Conrad | Marshall Russell | 1 |
| Victor Mohica | Billy Joe | 1 |
| David Sheiner | Wilson | 1 |
| Denver Pyle | Sgt. Tripp | 1 |
| Vera Miles | Beth | 1 |
| Horst Buchholz | Sergei | 1 |
| Lance LeGault | Wounded Soldier (uncredited) | 1 |
| Robert J. Wilke | Appleton | 1 |
| Read Morgan | Morton | 1 |
| Robert Ito | Chuk | 1 |
| Frank Ferguson | Grandpa | 1 |
| Soon-Tek Oh | Kee | 1 |
| Tom Simcox | Marshal Logan | 1 |
| Fran Ryan | 1 | |
| George DiCenzo | Tomaz | 1 |
| Trisha Noble | Valerie | 1 |
| Robert Donner | Soldier (uncredited) | 1 |
| Ben Davidson | 1 | |
| Bill Zuckert | Ship's Doctor | 1 |
| Bill Zuckert | Caldwell | 1 |
| Richard Davalos | Captain Olini | 1 |
| Luke Askew | 1 | |
| Rex Holman | Luther | 1 |
| John Pickard | Col. Caine | 1 |
| John Pickard | Jim Turner | 1 |
| David Dukes | 1 | |
| Booth Colman | 1 | |
| Joaquín Martínez | Amando Perez | 1 |
| Mark Withers | Tobe Harker | 1 |
| Lucille Benson | Miss Agnes | 1 |
| Lucille Benson | Miss Walker | 1 |
| Sarah Cunningham | 1 | |
| Richard Evans | Druey | 1 |
| Victor Sen Yung | Hospital Attendant | 1 |
| Bridget Hanley | Sheila | 1 |
| Martha Smith | Ellen Taylor | 1 |
| Gary Imhoff | 1 | |
| Claude Johnson | Wounded Soldier | 1 |
| Lawrence Levine | 1 | |
| Cliff Emmich | Bartender | 1 |
| Morgan Woodward | 0 | |
| Mills Watson | 0 | |
| Eva Marie Saint | Kate | 0 |
| Ramon Bieri | 0 | |
| Parley Baer | 0 | |
| Burton Gilliam | 0 | |
| Jared Martin | 0 | |
| Lucille Benson | 0 |