| Name | Character | Episodes |
|---|---|---|
| Patricia Routledge | Madame Mantalini | 6 |
| Nigel Havers | Nicholas Nickleby | 6 |
| Hilary Mason | Mrs. Nickleby | 6 |
| Derek Francis | Wackford Squeers | 6 |
| Preston Lockwood | Tim Linkinwater | 6 |
| Ron Pember | Mr. Snawley | 6 |
| Andrew McCulloch | John Browdie | 6 |
| Isabelle Amyes | Miss Fanny Squeers | 6 |
| Derek Godfrey | Ralph Nickleby | 6 |
| Patsy Smart | Miss La Creevy | 4 |
| Anthony Ainley | Sir Mulberry Hawk | 4 |
| Pauline Moran | Miss Petowker | 2 |
| Freddie Jones | Mr. Vincent Crummles | 2 |
| Liz Smith | Peg Sliderskew | 2 |
| Patricia Brake | Madeline Bray | 2 |
| Paul Pender | Mobbs | 2 |
| Edward Burnham | Lillyvick | 2 |
| Dennis Edwards | Walter Bray | 2 |
| Michael Brennan | Landlord | 1 |
| Gretchen Franklin | Miss Knag | 1 |