| Medicine could be a lucrative business if it weren't for all those sick people. So goes the motto of the mega-sized, mega-frugal HMO that runs Mission General Hospital in San Francisco, where two renegade doctors bend the rules and find the loopholes in a constant quest to treat their patients. Together, they practice medicine with a take-no-prisoners attitude and don't-take-no-for-an-answer tactics. |
| Name | Character | Episodes |
|---|---|---|
| William Fichtner | Dr. Bruce Kellerman | 11 |
| John Hannah | Dr. Robert Dalgety | 11 |
| Jane Lynch | Aileen Poole | 11 |
| Michaela Conlin | Dr. Maggie Yang | 11 |
| Robert Joy | Frank Coones | 11 |
| Aunjanue Ellis-Taylor | Quinn Joyner | 11 |
| Leslie Stefanson | Shelly Pangborn | 11 |
| Rainn Wilson | John Doe | 2 |
| Meera Simhan | Dr. Singh | 1 |
| Aimee Garcia | Gina Willis | 1 |
| Wade Williams | Big Thor Amundsen | 1 |
| Rosalind Chao | Angela Yuan | 1 |
| Michael Cudlitz | 1 | |
| Sheila Kelley | Pam Kellerman | 1 |
| James Pickens Jr. | 1 | |
| Amy Hill | 1 | |
| Thomas Lennon | Chester E. Donge | 1 |
| Michael Irby | Jaime Lopez | 1 |
| Marshall Bell | Bill 'Wise Guy' Weisman | 1 |
| Vernee Watson-Johnson | ER Admit Clerk #1 | 1 |
| Lindsay Frost | Linda Clark | 1 |
| Christine Tucci | Dr. Terri Calamari | 1 |
| Mark Adair-Rios | Que Paso | 1 |
| Nadia Dajani | 1 | |
| Matthew Yang King | 2nd Year Student | 1 |
| Tracy Vilar | ER Nurse #2 | 1 |
| Todd Kimsey | Tim Conley | 1 |
| Ricky Harris | Randy Stilton | 1 |
| Jennie Ventriss | Elderly Woman | 1 |
| Blayne Weaver | Smart Ass 2nd Year | 1 |
| Miguel Pérez | Mr. Lopez | 1 |
| Daniel Edward Mora | Father | 1 |
| Darryl Fong | EMT | 1 |
| Jenna Gering | Julia | 1 |
| Dan Bucatinsky | Kurt | 1 |
| Anjul Nigam | Nurse Manoj Nakshi | 1 |