| Name | Character | Episodes |
|---|---|---|
| George Burns | George Burns | 291 |
| Bea Benaderet | Blanche Morton | 291 |
| Gracie Allen | Gracie Allen | 291 |
| Harry von Zell | Harry von Zell | 265 |
| Larry Keating | Harry Morton | 159 |
| Robert Ellis | Ralph Grainger | 14 |
| Peter Brocco | Peter the Waiter | 8 |
| Valerie Allen | Verna Mason | 4 |
| Sheldon Leonard | Johnny Velvet | 2 |
| Sheldon Leonard | Silky Thompson | 2 |
| Kathryn Card | Mrs. Johnson | 2 |
| Myrna Fahey | Barbara Westrope | 2 |
| Herb Vigran | Cab Driver | 2 |
| John Eldredge | Floorwalker Willoughby | 2 |
| Douglass Dumbrille | Judge Strickland | 2 |
| Lyle Talbot | Al Simon | 2 |
| Elinor Donahue | Emily Vanderlip Foster | 1 |
| Joan Banks | Alice Rogers | 1 |
| Lester Matthews | Mr. Duffy | 1 |
| Lester Matthews | Mr. Larkin | 1 |
| Lester Matthews | Mr. Burke | 1 |
| Lester Matthews | Mr. Thomas Marshall | 1 |
| Lester Matthews | Professor Hopkins | 1 |
| Lester Matthews | Mr. Buzby | 1 |
| Lester Matthews | Mr. Fortune | 1 |
| Marion Ross | Dixie the Manicurist | 1 |
| Carl Reiner | Hotel Waiter | 1 |
| Will Wright | Judge Kramer | 1 |
| Sue George | Mildred Foster | 1 |
| John Stephenson | The Jewelry Clerk | 1 |
| John Stephenson | The Quizmaster | 1 |
| John Stephenson | The District Attorney | 1 |
| John Crawford | 1 | |
| Alan Mowbray | Professor Bradford | 1 |
| Jean Willes | Alice | 1 |
| Jean Willes | Alice Emory | 1 |
| Robert Cummings | 1 | |
| Ray Teal | Lt. Boyd | 1 |
| Martha Wentworth | Mrs. Gilbert | 1 |
| Ben Welden | Lefty | 1 |
| George E. Stone | Joe | 1 |
| Bob Sweeney | Mr. Dalton | 1 |
| Raymond Bailey | Dr. Bradley | 1 |
| Douglas Fowley | Charles Lowe | 1 |
| Paul Birch | Police Desk Sergeant | 1 |
| John Harmon | The Defendant | 1 |
| William Schallert | Pete | 1 |
| Mary Wickes | Waitress (uncredited) | 1 |
| Alberto Morin | Juan Rodriguez | 1 |
| Alberto Morin | José Sandoval | 1 |
| Claude Stroud | Mr. Walden | 1 |
| Claude Stroud | Mr. Billings | 1 |
| Irene Hervey | Clara Bagley | 1 |
| Irene Hervey | Florence Henderson | 1 |
| Kathryn Card | Mrs. Barlow | 1 |
| Kathryn Card | Mrs. Bellows - Cook | 1 |
| Hal Taggart | Herbert Browar | 1 |
| Hal Taggart | Mr. Wilson | 1 |
| Hal Taggart | The Hotel Clerk | 1 |
| Verna Felton | Mrs. Rodney | 1 |
| Verna Felton | Maggie | 1 |
| Verna Felton | Emily Marsh | 1 |
| Verna Felton | Mrs. Evans | 1 |
| Olaf Hytten | Cyril Blodgett | 1 |
| Frank Wilcox | Prof. Robert Gordon | 1 |
| Frank Wilcox | Michael Rockford | 1 |
| Frank Wilcox | Prof. Clinton | 1 |
| Frank Wilcox | Mr. Brooks | 1 |
| Fran Bennett | Marilyn | 1 |
| George Eldredge | Party Guest | 1 |
| George Eldredge | Detective Benson | 1 |
| Herb Vigran | The Man in the Dentist's Office | 1 |
| Herb Vigran | The Man with the Money Order | 1 |
| Herb Vigran | The Delivery Man | 1 |
| Robert Bray | Major Cunningham | 1 |
| Robert Bray | Detective Wilcox | 1 |
| Robert Bray | Don Emory | 1 |
| John Gallaudet | Sonny Werblin | 1 |
| Steve Reeves | Foley | 1 |
| Damian O'Flynn | Mr. Meeker | 1 |
| Damian O'Flynn | The Customer | 1 |
| Damian O'Flynn | Mr. Edward Colton | 1 |
| Don Brodie | Casey | 1 |
| Lomax Study | The Man at the Post Office | 1 |
| Lomax Study | Charles the Waiter | 1 |
| Richard Reeves | Luke | 1 |
| Leon Tyler | The Western Union Boy | 1 |
| Michael Whalen | Joe Bagley | 1 |
| Don Dillaway | Dr. Powell | 1 |
| Don Dillaway | The Doorman | 1 |
| Frank Mills | The Professor in Jail | 1 |
| Ray Bennett | The Man in Jail | 1 |
| Pat Flaherty | The Store Detective | 1 |
| Jana Lund | Annabelle Morris | 1 |
| Jack Benny | Jack Benny (uncredited) | 1 |
| Douglass Dumbrille | Mr. Arthur J. Cahill | 1 |
| Dick Gordon | Restaurant Patron (uncredited) | 1 |
| Sol Gorss | Henderson Brother | 1 |
| Valerie Allen | Imogene Reynolds | 1 |
| Mary Webster | Linda | 1 |
| Robert Ellis | Frank Foster | 1 |
| Robert Ellis | Charlie | 1 |
| Jack Gargan | The TV Program Assistant | 1 |
| Alexander Campbell | Mr. Shaw | 1 |
| John Brown | Harry Morton | 1 |
| Dan Tobin | The Guide | 1 |
| George Pembroke | Mr. Ferguson | 1 |
| George Pembroke | Detective Roach | 1 |
| Mary Treen | Mrs. Curtis | 1 |
| Noel Drayton | Mr. Sheridan | 1 |