| Name | Character | Episodes |
|---|---|---|
| Gabriel Basso | Adam Jamison | 40 |
| Laura Linney | Cathy Jamison | 40 |
| Oliver Platt | Paul Jamison | 40 |
| John Benjamin Hickey | Sean Tolkey | 40 |
| Phyllis Somerville | Marlene | 15 |
| Gabourey Sidibe | Andrea Jackson | 14 |
| Phill Lewis | Cool pool boss | 13 |
| Michael Chernus | Pastor Rick | 4 |
| Emily Kinney | Emily | 3 |
| Brian d'Arcy James | Tim | 3 |
| Liz Holtan | Amber | 2 |
| Brian Dennehy | Dad | 1 |
| Cynthia Nixon | Rebecca | 1 |
| Angela Lewis | Day Nurse | 1 |
| David Aaron Baker | Priest | 1 |
| Kathy Najimy | Cathy's Therapist | 1 |
| Ned Eisenberg | Dr. Volimer | 1 |
| David Wilson Barnes | Wesley | 1 |
| Reid Scott | Todd Mauer | 1 |
| Judy Gold | Rabbi | 1 |
| Isaac Mizrahi | Self | 1 |
| Connie Ray | Connie Schuler | 1 |
| Rosemary Howard | Hospice Visitor (uncredited) | 1 |
| Rebecca Watson | Blonde Woman (uncredited) | 1 |
| Darlene Hunt | Hospice Administrator | 1 |
| Ann Harada | Brenda | 1 |