| Name | Character | Episodes |
|---|---|---|
| Joel Kinnaman | Stephen Holder | 44 |
| Mireille Enos | Sarah Linden | 44 |
| Annie Corley | Regi Darnell | 38 |
| Michelle Forbes | Mitch Larsen | 26 |
| Kristin Lehman | Gwen Eaton | 26 |
| Billy Campbell | Darren Richmond | 26 |
| Jamie Anne Allman | Terry Marek | 26 |
| Eric Ladin | Jamie Wright | 26 |
| Brendan Sexton III | Belko Royce | 26 |
| Brent Sexton | Stanley Larsen | 26 |
| Seth Isaac Johnson | Denny Larsen | 22 |
| Evan Bird | Tom Larsen | 22 |
| Liam James | Jack Linden | 13 |
| Katie Findlay | Rosie Larsen | 13 |
| Peter Sarsgaard | Ray Seward | 12 |
| Elias Koteas | James Skinner | 12 |
| Max Fowler | Twitch | 12 |
| Bex Taylor-Klaus | Bullet | 12 |
| Amy Seimetz | Danette | 12 |
| Hugh Dillon | Francis Becker | 12 |
| Julia Sarah Stone | Lyric | 12 |
| Ashley Johnson | Amber Ahmed | 7 |
| Callum Keith Rennie | Rick Felder | 7 |
| Joan Allen | Margaret O'Neal | 6 |
| Gregg Henry | Carl Reddick | 6 |
| Levi Meaden | AJ Fielding | 6 |
| Sterling Beaumon | Lincoln Knopf | 6 |
| Jewel Staite | Caroline Swift | 5 |
| John Reardon | Charles Ross | 2 |
| Alona Tal | 1 | |
| Marin Ireland | Liz Holder | 1 |
| Michael Mando | Vasquez | 1 |
| Brian Markinson | Gil Sloane | 1 |
| Ben Cotton | Pastor Mike | 1 |
| Camille Sullivan | Meg Connell | 1 |
| Patti Allan | Bev Royce | 1 |
| Tantoo Cardinal | Hooker | 1 |
| Erica Tremblay | Kayla | 1 |
| Tyler Johnston | Alexi Giffords | 1 |
| Laine MacNeil | Angie Gower | 1 |
| Murry Peeters | Janice Gibbs (as Murry Peters) | 1 |
| Andrey Batt | Hijacker | 1 |