| Name | Character | Episodes |
|---|---|---|
| Kate Mulgrew | Kove | 39 |
| Peter Serafinowicz | SAM (voice) | 39 |
| Rob Riggle | President of the Navy | 39 |
| Martin Starr | Sam Stern | 39 |
| June Diane Raphael | Piper Ferguson | 39 |
| Paul Scheer | Trent Hauser | 39 |
| Brandon Johnson | Alphonse | 39 |
| Rebecca Romijn | Jessie Nichols | 27 |
| Karen Gillan | Daisy | 12 |
| Aubrey Plaza | The Rememberer | 2 |
| J.K. Simmons | Frank Forrest | 1 |
| Adam Scott | Van Damm | 1 |
| Kathryn Hahn | Marge | 1 |
| Brie Larson | Katerin | 1 |
| Mark Hamill | Lundgren (voice) | 1 |
| Martin Kove | Cell Leader | 1 |
| Gabrielle Union | Sandy Canyons | 1 |
| Kelly Brook | Anna | 1 |
| Lorenzo Lamas | Felipe Calderon | 1 |
| Tony Hale | Dr. Karl | 1 |
| Kerri Kenney | 4-Sight | 1 |
| John Gemberling | Bruce | 1 |
| Johnny Ray Meeks | Guard (as Johnny Meeks) | 1 |
| John Cho | Chip | 1 |
| Ed Helms | Eddie | 1 |
| Casey Wilson | Ghost Gabber | 1 |
| Carly Chaikin | Brittany | 1 |
| Jon Daly | Chad | 1 |
| Erik Betts | Bad Guy #2 | 1 |
| Rich Fulcher | Elena | 1 |
| Dave Allen | Crowley Morehouse | 1 |
| Esteban Cueto | Guard | 1 |
| Jonny Coyne | Craig | 1 |
| Gil Ozeri | College Kid 3-D | 1 |
| Laura Chinn | Mitzi (uncredited) | 1 |
| Marco Morales | Delivery Man | 1 |
| Deanna Cheng | Neighbor's Wife (as Deanna Raphael) | 1 |