| Major Crimes explores how the American justice system approaches the art of the deals as law enforcement officers and prosecutors work together to score a conviction. Los Angeles Police Captain Sharon Raydor heads up a special squad within the LAPD that deals with high-profile or particularly sensitive crimes. |
| Name | Character | Episodes |
|---|---|---|
| Mary McDonnell | Captain Sharon Raydor | 105 |
| Raymond Cruz | Detective Julio Sanchez | 105 |
| Nadine Velazquez | D.D.A. Emma Rios | 105 |
| G.W. Bailey | Lt. Louie Provenza | 105 |
| Tony Denison | Lt. Andy Flynn | 105 |
| Graham Patrick Martin | Rusty Beck | 105 |
| Kearran Giovanni | Amy Sykes | 105 |
| Michael Paul Chan | Lt. Mike Tao | 105 |
| Phillip P. Keene | Buzz Watson | 105 |
| Rene Rosado | Gustavo "Gus" Wallace | 30 |
| Jonathan Del Arco | Dr. Morales | 29 |
| Robert Gossett | Assistant Chief Taylor | 29 |
| Daniel Di Tomasso | Detective Wes Nolan | 19 |
| Carlos Ponce | Mr. Emilio Diaz | 13 |
| Ever Carradine | Sharon Beck | 10 |
| Brandon Barash | Detective Robby Oderno | 6 |
| Ransford Doherty | Kendall | 6 |
| Ian Bohen | Daniel Dunn | 3 |
| Jaime Ray Newman | Wildred Darnell | 3 |
| Sonya Leslie | Cynthia | 3 |
| Malcolm-Jamal Warner | Lt. Chuck Cooper | 2 |
| Anthony Keyvan | Lucas Garza | 2 |
| Kathe Mazur | D.D.A. Andrea Hobbs | 2 |
| America Olivo | Liseth Ortiz | 2 |
| Jon Tenney | Agent Fritz Howard | 2 |
| Bill Brochtrup | Dr. Joe Bowman | 2 |
| Adam Irigoyen | Jesus Marquez | 2 |
| Alice Greczyn | Vanessa Blaine | 2 |
| Lenny Jacobson | Erik Walsh | 2 |
| Ron Marasco | Judge Grove | 2 |
| Jeri Ryan | Linda Rothman | 1 |
| Michael Nouri | Congressman Steven Keller | 1 |
| Tanner Buchanan | Michelle Brand | 1 |
| David Mazouz | Steve | 1 |
| Esai Morales | Deputy Manuel Diaz | 1 |
| Xolo Mariduena | Stefan Camacho | 1 |
| Amy Bailey | Karina Volsky | 1 |
| Teresa Ruiz | Monica Garcia | 1 |
| Torrey DeVitto | Nicole | 1 |
| Alyson Reed | Mrs. Lowe | 1 |
| Shanna Collins | Robyn Harris | 1 |
| Darrell Britt-Gibson | Shorty Wallace | 1 |
| Markus Flanagan | Dr. Carl Riley | 1 |
| Noah Crawford | Connor Price | 1 |
| Tom Parker | Ted King Jr. | 1 |
| Ross Butler | Ian Yorita | 1 |
| Thad Luckinbill | Hunt Massey | 1 |
| Nathan Kress | Tyler Lang | 1 |
| Jim Beaver | Donald Beckwith | 1 |
| Chris Browning | Mustache | 1 |
| Nick E. Tarabay | Jason Goss | 1 |
| Jason London | Chris Harris | 1 |
| Rebecca Wisocky | Madeline Morgan | 1 |
| Dan Castellaneta | Ray Winters | 1 |
| Kenneth Mitchell | Sam Curtis | 1 |
| Rick Fox | Rick Fox | 1 |
| Leslie Grossman | Claire Hunter | 1 |
| Jesse McCartney | Dawson Tucker Yale | 1 |
| Josh Randall | Detective Sean Mackeroy | 1 |
| Nikki DeLoach | Corporal Laura Day | 1 |
| Skye P. Marshall | Makisha Selby | 1 |
| Chris Wood | Brandon North | 1 |
| Raoul Max Trujillo | Javier Mendoza | 1 |
| John Aylward | Ted King Sr. | 1 |
| Madison McLaughlin | Kris Slater | 1 |
| Clare Carey | Mrs. Riley | 1 |
| Conor Leslie | Mary Lowe | 1 |
| Matt O'Leary | Alex Wilson | 1 |
| Lauren Stamile | 1 | |
| Myndy Crist | Selma Hewitt | 1 |
| Chris Brochu | Josh Allen | 1 |
| Luke Cook | Joey Bowie | 1 |
| Charlene Amoia | Kelly Press | 1 |
| John Ales | Martin Elliot | 1 |
| Joel Brooks | Gary Bridges | 1 |
| Amir Talai | Geoff Klein | 1 |
| Reiley McClendon | Benny | 1 |
| Rita Volk | Briana Mathis | 1 |
| Devon Graye | Ryan Keller | 1 |
| Jon Polito | Dino Kotero | 1 |
| Reiko Aylesworth | Dr. Jane Cross | 1 |
| Brooke Nevin | Mrs. Palmer | 1 |
| Christopher Cousins | Dr. Charles Mason | 1 |
| Michael Hyatt | Jada Roads | 1 |
| Devon Werkheiser | Officer Cooper | 1 |
| Jason Dolley | James Martin Elliott aka 'J-Me' | 1 |
| Augustus Prew | Billy | 1 |
| Augustus Prew | Wade Weller aka Ryan Mills | 1 |
| Molly Burnett | Kim Riley | 1 |
| Bridger Zadina | Wyatt Duncan | 1 |
| Joe Flanigan | Rick Marlow | 1 |
| Jeanine Mason | Heather | 1 |
| Amy Davidson | Allison fisher | 1 |
| Molly Stanton | Olivia King | 1 |
| John D'Aquino | Craig Fowler | 1 |
| James MacDonald | Lt. Reed | 1 |
| Tamara Mello | Jordan Garcia | 1 |
| John Lacy | Jimmy Bosch | 1 |
| Jansen Panettiere | Reed Downy / Rory Brooks | 1 |
| Carole Cook | Marcella Brewster | 1 |
| Gavin Stenhouse | Jason Dietz | 1 |
| Sydney Walsh | Susan Mills | 1 |
| Jessica Lundy | Aubrey Dietz | 1 |
| Jon Wellner | Attorney | 1 |
| Susan James Berger | Mary Conrad | 1 |
| Diego Delpiano | Tim Greggs | 1 |
| Shannon Dang | Sushi Hostess | 1 |
| Rick Peters | Michael Harris | 1 |
| Susan Grace | Mark's Grandma | 1 |
| Alejandra Flores | Mrs. Herrera | 1 |
| Pamela Dunlap | Lorraine North | 1 |
| Tim Chiou | Ken Song | 1 |
| Yaani King Mondschein | Mrs. Walker | 1 |
| Caitlin Custer | Raquel Newman | 1 |
| Richie Stephens | Marcus Kemp | 1 |
| Alani iLongwe | T-Ray Jackson | 1 |
| Nic Robuck | Darren Talbot | 1 |
| Jermel Howard | Miller | 1 |
| Will Shadley | Mike | 1 |
| Angel Oquendo | 1 | |
| Jakobe Dempsey | Darryl Walker | 1 |
| Carlos Moreno Jr. | Florentino Reyes | 1 |
| Peter Katona | Alex Bennett | 1 |
| Scott Bailey | Robert Keller | 1 |