| Martin Bohm, a widower and single father, is haunted by an inability to connect to his autistic, mute 11-year-old son, Jake. Their relationship and their lives take an extraordinary turn when he discovers his gifted son has the ability to see things that no one else can and the patterns that connect seemingly unrelated events. |
| Name | Character | Episodes |
|---|---|---|
| Kiefer Sutherland | Martin Bohm | 26 |
| David Mazouz | Jacob Bohm | 26 |
| Gugu Mbatha-Raw | Clea Hopkins | 13 |
| Greg Ellis | Trevor Wilcox | 13 |
| Lukas Haas | Calvin Norburg | 13 |
| Saxon Sharbino | Amelia Robbins | 13 |
| Maria Bello | Lucy Robbins | 10 |
| Saïd Taghmaoui | Guillermo Ortiz | 10 |
| Bodhi Elfman | Avram Hadar | 10 |
| Roxana Brusso | Sheri Strepling | 9 |
| Frances Fisher | Nicole Farington | 5 |
| Danny Glover | Professor Arthur Teller | 5 |
| Linda Gehringer | Frances | 5 |
| Mykelti Williamson | Detective Lang | 4 |
| Catherine Dent | Abigail Kelsey | 4 |
| D. B. Sweeney | Joseph Tanner | 4 |
| John Boyd | Kase | 4 |
| Adam Campbell | Tony Rigby | 4 |
| Isabella Acres | Soleil Friedman | 4 |
| Ray Santiago | Reuben Santiago | 4 |
| Titus Welliver | Randall Meade | 3 |
| Leland Orser | Dr. Linus | 3 |
| David de Lautour | Simon Plimpton | 3 |
| John Prosky | Lawrence Pearl | 3 |
| Randy Oglesby | Carl Hirsch | 3 |
| Allegra Carpenter | Celeste | 2 |
| Jude Ciccolella | Arnie Klepper | 2 |
| Rob Benedict | Walt King | 2 |
| Dileep Rao | Vikash Nayar | 2 |
| Sumalee Montano | Nurse Liz | 2 |
| Amy Sloan | Becca Klepper | 2 |
| Bernard White | Dr. Robert McCormick | 2 |
| Shak Ghacha | Abdul Kozari | 2 |
| Elijah Alexander | Yosef | 2 |
| Annie Wersching | Dr. Kate Gordon | 1 |
| Keith David | Dutch | 1 |
| Manuel Garcia-Rulfo | Father Esteban | 1 |
| Anne Dudek | Allegra | 1 |
| Wade Williams | Braeden | 1 |
| Tamlyn Tomita | Kazuko Osugi | 1 |
| Katherine McNamara | Evie Woods | 1 |
| Ray Ford | Cell Company Workman | 1 |
| Johnny Kostrey | Corporal Magnus Shea | 1 |
| Eijiro Ozaki | Japanese Businessman | 1 |
| Patricia Bethune | Miss Herrera | 1 |
| Dimiter D. Marinov | Taxi Driver | 1 |
| Margaret Easley | Nurse Judy | 1 |
| Blair Hickey | Step-Dad | 1 |
| Stephen 'tWitch' Boss | The Beastmaster | 1 |
| Meera Simhan | Simrin | 1 |
| Mark Kelly | Nick Fowler | 1 |
| Castulo Guerra | Father San Felipo | 1 |
| Don Harvey | Joey Deluca | 1 |
| Christopher May | Unfriendly Man | 1 |
| Jamie McShane | Mike O'Brien | 1 |
| John Getz | Henry Williams | 1 |
| Melissa Ponzio | Gwen Davis | 1 |
| Mary Stuart Masterson | Beth Cooper | 1 |
| Ayelet Zurer | Rosemary Mathis | 1 |
| Eric Lange | Dr. Stanley | 1 |
| Sprague Grayden | First Lieutenant Laura Davis | 1 |
| Matthew Glave | Frank Robbins | 1 |
| Matt McCoy | Lamont | 1 |
| Ron Rifkin | Isaac | 1 |
| Tony Brubaker | Bus Driver | 1 |
| Francis Capra | Biker Guy | 1 |
| Monique Gabriela Curnen | Lisette | 1 |
| Scott Michael Campbell | John Tenney | 1 |
| Krys Marshall | Claire | 1 |
| Mackenzie Astin | Mr. Kane | 1 |
| Audrey Marie Anderson | Mallory Kane | 1 |
| Brent Jennings | Medical Examiner | 1 |
| Karen David | Kayla Graham | 1 |
| Olesya Rulin | Red Dress | 1 |
| Karan Soni | Ravi | 1 |
| Deborah Van Valkenburgh | Dee Dee | 1 |
| Marisa Petroro | Ipolita | 1 |
| Gabriel Luna | Ted | 1 |
| Jeremiah Birkett | Larry | 1 |
| George Wyner | Lee Zedner | 1 |
| William Ragsdale | Travis Cooper | 1 |
| Anthony Molinari | Guard | 1 |
| Mark Rolston | Ed | 1 |
| Robert Romanus | Nelson | 1 |
| Ray Proscia | Frederick LeMay | 1 |
| Mark Ivanir | Yuri Andreev | 1 |
| Tiya Sircar | Veronique / Nandu | 1 |
| Joshua Leonard | King Roadie | 1 |
| Toshi Toda | Hiroshi | 1 |
| Julian Barnes | Doctor | 1 |
| Dante Brown | Thabo | 1 |
| Kirk B.R. Woller | Private Detective | 1 |
| Ravi Kapoor | Cabbie | 1 |
| Amir Talai | Sami | 1 |
| Travis Aaron Wade | Shane Stevens | 1 |
| Angela Gots | Stacey | 1 |
| Natalie Lander | College Girl | 1 |
| Karen Strassman | Receptionist | 1 |
| Kofi Natei | Foreman | 1 |
| Scott Klace | Ben Miller | 1 |
| Ravil Isyanov | Landlord | 1 |
| Louis Ferreira | Felipe | 1 |
| Arturo del Puerto | Jorge | 1 |
| Rizwan Manji | Pakistani Interrogator | 1 |
| Mari Morrow | Ann-Marie | 1 |
| David Ury | Rizzi | 1 |
| Randall Batinkoff | Patrick McGrath | 1 |
| Michelle Krusiec | Lanny Cheong | 1 |
| Blake Bertrand | Max O'Brien | 1 |
| Ron Yuan | Wember Hsu | 1 |
| Nadine Ellis | Coroner | 1 |
| Anna Diop | Lila James | 1 |
| Slade Pearce | Quest Boy | 1 |
| Jim Piddock | Dr. Knox | 1 |
| Carlease Burke | Clea's Mother | 1 |
| Graham Hamilton | Rush Middleton | 1 |
| Rob Nagle | Detective Latham | 1 |
| Ursula Burton | PR Person | 1 |
| Alan Blumenfeld | Poker Player | 1 |
| James Handy | Lanford Biddle | 1 |
| Sundra Oakley | Thomas Becko | 1 |
| Vincent Guastaferro | Sal | 1 |
| Tacey Adams | Receptionist | 1 |
| Gonzalo Menendez | Cooper | 1 |
| Rolando Molina | Hector | 1 |
| Peter Murnik | Officer McKinney | 1 |
| Harvey J. Alperin | Old Hasidic Jew | 1 |
| Dahlia Salem | Jeweler | 1 |
| John Lacy | Jerry Woods | 1 |
| David Lengel | Lab Tech | 1 |
| Susan Angelo | Jeanne Black | 1 |
| Kwesi Boakye | Farai | 1 |
| Kat Purgal | Colleen | 1 |
| Alberto Frezza | Paolo | 1 |
| Skyler Stone | DJ Oliver | 1 |
| Blake Shields | Peanut Vendor | 1 |
| Jacqueline Scislowski | Amelia Robbins | 1 |
| Mike Batayeh | Arnie's Friend | 1 |
| Emma Pasarow | Tween Girl | 1 |
| Marcus Choi | Security Guard | 1 |
| Kiko Ellsworth | Bobby Aresa | 1 |
| Elijah Nelson | Matt King | 1 |
| Bart McCarthy | Constable | 1 |
| Ricky Russert | Burly Man | 1 |
| Phil Miler | Alfredo | 1 |
| Christina Scherer | Julie | 1 |
| Jennifer Riker | Det. Rose Tyler | 1 |
| Maggie Egan | Shop Owner | 1 |
| Simon Delaney | Niles Borne | 1 |
| Aline Elasmar | Arab Woman | 1 |
| Sean Carrigan | Security Guard | 1 |
| Bill Parks | Philip | 1 |
| Amelia Rose Blaire | Natalie | 1 |
| Christopher Murray | Montreal Doctor | 1 |
| Tatiana Chekhova | Pavel's Mom | 1 |
| Khanya Mkhize | Sauda | 1 |
| Rafael J. Noble | Bus Station Clerk | 1 |
| David Julian Hirsh | Will Davies | 1 |
| Michael Broderick | Guard | 1 |
| Brett Wagner | Security Guy | 1 |
| Jamie Martz | Sullivan | 1 |
| Charles Henry Wyson | Colin Davis | 1 |
| Alex Ruiz | Vicente Corliss | 1 |
| Alec Medlock | Nicole's Assistant | 1 |
| Jernard Burks | Jimar Becko | 1 |
| Brian Groh | Player | 1 |
| Corey Michael Eubanks | Businessman | 1 |
| Ian Alda | Nervous Young Man | 1 |
| Jackson Davis | Zack | 1 |
| Sherri Parker Lee | Jackie | 1 |
| Iyad Hajjaj | Norah's Father | 1 |
| Patricia Rae | Sophia Corliss | 1 |
| Brian Maillard | Randy Kitson | 1 |
| Jay Harik | Rich Father | 1 |
| Anthony Alabi | Gate Guard | 1 |
| Charlet Chung | Mandy Hsu | 1 |
| Sean McGowan | Devon Michael Jones | 1 |
| Salman Bokhari | Pakistani Officer | 1 |
| Kelly Keaton | Nurse | 1 |
| Jeremy Luke | Dealer | 1 |
| Daniel Polo | Pavel Andreev | 1 |
| Javier Calderon | Lost and Found Guy | 1 |
| Craig Stepp | Anchorman | 1 |
| Nick Jaine | Lab Tech | 1 |
| Vince Grant | Charlie King | 1 |
| Amol Shah | Pakistani Officer | 1 |
| Camille Chen | Serena | 1 |
| Robert Pike Daniel | Zeke | 1 |
| Melissa Carnell | Metro Girl | 1 |
| Sanjay Chandani | Nazim Farzat | 1 |
| Kevin E. West | Dixon | 1 |
| JJ Snyder | News Anchorwoman | 1 |
| Hiram A. Murray | LAPD Cop | 1 |
| Kavi Raz | Sanjay Nayar | 1 |
| Tony Pasqualini | Boss | 1 |
| Pippa Hinchley | Therapist | 1 |
| David H. Lawrence XVII | Morgue Worker | 1 |
| Stevens Gaston | Security Guard | 1 |
| Ransford Doherty | Park Ranger | 1 |
| Franco Vega | State Trooper | 1 |
| Carlos Ragas | Thug | 1 |
| Joe Abraham | Man in Laundry Service Uniform | 1 |
| Ana Maria Lagasca | Isidora | 1 |
| Janeline Hayes | Young Waitress | 1 |
| Joey Naber | Abdul's Father | 1 |
| Kevin Rock | Lead Guy | 1 |
| Daniel Steven Gonzalez | Prison Guard | 1 |
| Ian Gomez | Wade | 1 |
| Candice Coke | Patricia Grimes | 1 |
| Jack Guzman | Big Man | 1 |
| Maria Quiban | Morning Weather Girl | 1 |
| Eyal Podell | Professor Logan Coteweiler | 1 |
| Alexandra Peters | Russian Girl | 1 |