| A biennial charitable telethon bringing together all the networks and the biggest stars in entertainment, for one night of music, laughter, and inspiration. The aim is to raise significant funds for translational cancer research, raise awareness, and bring about an understanding that everyone is connected to cancer. |
| Name | Character | Episodes |
|---|---|---|
| Scarlett Johansson | Self | 1 |
| Josh Brolin | Self | 1 |
| Mahershala Ali | Self | 1 |
| Kathy Bates | Self | 1 |
| Jason Bateman | Self | 1 |
| Gwyneth Paltrow | Self - Host | 1 |
| Julie Bowen | Self | 1 |
| Katie Couric | Self | 1 |
| Katie Couric | Self - Host | 1 |
| Beth Behrs | Self | 1 |
| Stevie Wonder | Self - Performer | 1 |
| Jade Thirlwall | Self | 1 |
| Perrie | Self | 1 |