| Name | Character | Episodes |
|---|---|---|
| Claudia Michelsen | Ann Gittel | 22 |
| Oliver Bröcker | Henner Blum | 22 |
| Samuel Finzi | Dr. Vincent Flemming | 22 |
| Anna Thalbach | Dr. Alissa Markus | 22 |
| Maren Kroymann | Walli Hoven | 22 |
| Götz Schubert | Robert Anda | 22 |
| Hanns Zischler | Dr. Hans Matthei | 4 |
| Rainer Sellien | Kolja Geyger | 4 |
| Arndt Schwering-Sohnrey | Kalle Ux | 3 |
| Lavinia Wilson | Henny Rohde | 1 |
| Inga Busch | Irm Fokken | 1 |
| Kirsten Block | Frau Leo | 1 |
| Jean-Yves Berteloot | Dr. Baschyi Aschurew | 1 |
| Martin Brambach | Stefan Aspeck | 1 |
| Gesine Cukrowski | Viola Seddler | 1 |
| Anian Zollner | Mark Leidhoff | 1 |
| Jana Pallaske | Fenja Landers | 1 |
| Alexander Held | Dr. Arnulf Rand | 1 |
| Edin Hasanović | Matti Grube | 1 |
| Christoph Maria Herbst | Severin Grevesmühlen | 1 |
| Julia Jäger | Nathalie Lenbach | 1 |
| Nicolette Krebitz | Dr. Yvonne Lederer | 1 |
| Oliver Stokowski | Ludger Simbek | 1 |
| Natalia Wörner | Senta Warburg | 1 |
| Kathrin Angerer | Ellen Lambert | 1 |
| Deborah Kaufmann | Katharina Rand | 1 |
| Brigitte Janner | Bruni Gehrken | 1 |
| Armin Dillenberger | 1 | |
| Jan Henrik Stahlberg | Thomas Vega | 1 |
| Justus von Dohnányi | Prof. Dr. Axel Farkas | 1 |
| Niels-Bruno Schmidt | Tony Kuttner | 1 |
| Bernd Michael Lade | Peter Mersheim | 1 |
| Erol Sander | Dr. Baschar Al-Rif | 1 |
| Harald Schrott | Konrad Grube | 1 |
| Denise Virieux | Maya Hagenau | 1 |
| Melika Foroutan | Tonja Rauh | 1 |
| Sebastian Blomberg | Klaus Koch | 1 |
| Wolfram Koch | Dr. Kilian Roll | 1 |
| Max Befort | Vaclav Kern | 1 |
| Peter Davor | Peter Remy | 1 |
| Hansa Czypionka | Leonard Seddler | 1 |
| Franziska Petri | Valerie Venhaus | 1 |
| Tamara Simunovic | Mascha Bloch | 1 |
| Tobias Langhoff | 1 | |
| Michael Lott | Lutz Färber | 1 |
| Jürgen Tarrach | Jörg Backfeld | 1 |
| Johanna Gastdorf | Sandra Schweikert | 1 |
| Bernd Stegemann | Rolf Hagenau | 1 |
| Sheri Hagen | Agnes Stieglitz | 1 |