| Tsubomi Hanasaki is a girl in the second grade of middle school who likes flowers and plants. One day she experiences a weird dream. In that dream, a large blooming tree appears. Suddenly, it loses all of its flowers and 2 fairies appear. A few days later after Tsubomi has transferred to Myoudou Academy, suddenly the fairies from the dream appear before her and plead to Tsubomi to become the legendary warrior Pretty Cure, and protect the Heart Tree. However, Tsubomi declines as she doesn't think that she would be able to do that. However, a mysterious enemy suddenly strikes and steals the Heart Flower of her classmate, Erika Kurumi. Now she doesn't have a choice. To retrieve Erika's Heart Flower, she has to transform into a Pretty Cure and fight. Working up the courage, Tsubomi turns into Cure Blossom and a new chapter of Pretty Cure begins! |
| Name | Character | Episodes |
|---|---|---|
| Rei Sakuma | Haruna Tsukikage (voice) | 49 |
| Minami Takayama | Dark Pretty Cure (voice) | 49 |
| Wakana Yamazaki | Aki Horiuchi (voice) | 49 |
| Aya Hisakawa | Yuri Tsukikage / Cure Moonlight (voice) | 49 |
| Kikuko Inoue | Keiko Ban (voice) | 49 |
| Yuri Amano | Mayuka (voice) | 49 |
| Ai Orikasa | Yuuki Hayashi (voice) | 49 |
| Akeno Watanabe | Sayaka (voice) | 49 |
| Fumiko Orikasa | Azusa Takagishi (voice) | 49 |
| Sakiko Tamagawa | Rumi Shiku (voice) | 49 |
| Yumi Kakazu | Karin Tsuyuki (voice) | 49 |
| Hiromi Tsuru | Heart Tree (voice) | 49 |
| Fumihiko Tachiki | Masakazu Harano (voice) | 49 |
| Ryotaro Okiayu | Kenji Ban (voice) | 49 |
| Atsuko Yuya | Tsubaki Myōdōin (voice) | 49 |
| Chika Sakamoto | Kaoruko Hanasaki (voice) | 49 |
| Keiichi Sonobe | Masajirō Harano (voice) | 49 |
| Daisuke Ono | Daiki (voice) | 49 |
| Hirofumi Nojima | Cobraja (voice) | 49 |
| Takashi Matsuyama | Akira's father (voice) | 49 |
| Akira Ishida | Cologne (voice) | 49 |
| Koichi Tochika | Ryūnosuke Kurumi (voice) | 49 |
| Sachiko Kojima | Kanae Tada (voice) | 49 |
| Tomoko Kaneda | Desertrians (voice) | 49 |
| Miki Nagasawa | Masato Sakai (voice) | 49 |
| Taeko Kawata | Shypre (voice) | 49 |
| Chado Horii | Sunakey (voice) | 49 |
| Shizuka Itoh | Momoka Kurumi (voice) | 49 |
| Hikaru Midorikawa | Dune (voice) | 4 |