| NYC 22 follows six diverse NYPD rookies as they patrol the gritty streets of upper Manhattan. With unique backgrounds, personalities and reasons for being on the force, the new cops will make their share of rookie mistakes while they figure out how to relate to their boss, each other and the people they swore to protect. |
| Name | Character | Episodes |
|---|---|---|
| Leelee Sobieski | Jennifer 'White House' Perry | 13 |
| Stark Sands | Kenny McLaren | 13 |
| Adam Goldberg | Ray 'Lazarus' Harper | 13 |
| Terry Kinney | Daniel 'Yoda' Dean | 13 |
| Felix Solis | Terry Howard | 13 |
| Tom Reed | Ahmad 'Kiterunner' Khan | 13 |
| Armand Schultz | Dr. Evan Roth | 13 |
| Judy Marte | Tonya Sanchez | 13 |
| Harold 'House' Moore | Jayson 'Jackpot' Toney | 13 |
| Giancarlo Esposito | Harvey Williams | 1 |
| Casey Siemaszko | Blume | 1 |
| Babs Olusanmokun | Fouad | 1 |
| John Amos | Pappy Science | 1 |
| Sonequa Martin-Green | Michelle Terry | 1 |
| Michael Kostroff | Brandon Ken | 1 |
| Adriane Lenox | sheila Gordon | 1 |
| Eric Nelsen | Hazzard | 1 |
| Lizzy DeClement | Ruby Harper | 1 |
| Vondie Curtis-Hall | Fred Wheeler | 1 |
| Mark Zimmerman | Dr. Friedman | 1 |
| Sheila Vand | Jasmeen | 1 |
| Daniel Sauli | Martini | 1 |
| Matthew Gumley | Carl | 1 |
| James Andrew O'Connor | Detective Rice | 1 |
| D.K. Bowser | Resident #5 | 1 |
| Debargo Sanyal | Dr. Choudry | 1 |
| Robert Kelly | Moore | 1 |
| Genevieve Hudson-Price | Apple | 1 |
| Bambadjan Bamba | Livery Driver | 1 |
| Reggie Alvin Green | Earl | 1 |
| Mark Tallman | Greg | 1 |
| Eric J Carlson | Officer Walters (uncredited) | 1 |
| Kevin McCormick | Shannon Bar Thug | 1 |
| Ephraim Benton | Resident #2 | 1 |
| Arthur French | Angry 'Old School' Resident | 1 |
| Simon Pearl | Yuppie | 1 |