| Rayna Jaymes and Juliette Barnes face personal and professional challenges as they navigate their paths as artists and individuals. Surrounding them, and often complicating their lives, are their family, friends and, in some cases, lovers, as well as the up-and-coming performers and songwriters trying to get ahead in the business. |
| Name | Character | Episodes |
|---|---|---|
| Hayden Panettiere | Juliette Barnes | 124 |
| Charles Esten | Deacon Claybourne | 124 |
| Maisy Stella | Daphne Conrad | 124 |
| Jonathan Jackson | Avery Barkley | 124 |
| Sam Palladio | Gunnar Scott | 124 |
| Clare Bowen | Scarlett O'Connor | 124 |
| Connie Britton | Rayna James | 108 |
| Eric Close | Teddy Conrad | 87 |
| Chris Carmack | Will Lexington | 87 |
| David Alford | Bucky Dawes | 65 |
| Judith Hoag | Tandy Hampton | 40 |
| Oliver Hudson | Jeff Fordham | 22 |
| Will Chase | Luke Wheeler | 22 |
| Powers Boothe | Lamar Wyatt | 21 |
| Robert Wisdom | Coleman Carlisle | 21 |
| Aubrey Shea | Layla Grant | 21 |
| JD Souther | Watty White | 21 |
| Kyle Dean Massey | Kevin Bicks | 15 |
| Chloe Bennet | Hailey | 7 |
| Pam Tillis | Herself | 7 |
| Susan Misner | Stacey | 5 |
| Rhiannon Giddens | Hallie Jordan | 5 |
| Elpidia Carrillo | Linda Brenner | 3 |
| Dylan Arnold | Twig | 3 |
| Christina Aguilera | Jade St. John | 3 |
| Mandy June Turpin | Cynthia Davis | 3 |
| Aubrey Shea | Layla | 3 |
| Cody Longo | Quentin | 2 |
| Alexa PenaVega | Kiley Brenner | 2 |
| Jeananne Goossen | Vita Martin | 2 |
| Keean Johnson | Colt Wheeler | 2 |
| Jason Douglas | Dashell Brinks | 2 |
| Lachlan Watson | Kyle | 2 |
| Boo Arnold | Brock Butler | 2 |
| Dana Wheeler-Nicholson | Beverly | 2 |
| Shane McRae | Patrick | 2 |
| Richard Lee Jackson | Bandmate | 2 |
| Joseph David-Jones | Clayton Carter | 2 |
| Ming-Na Wen | Calista Reeve | 1 |
| Kimberly Williams-Paisley | Peggy Kenter | 1 |
| Rya Kihlstedt | Marilyn Rhodes | 1 |
| Rex Linn | Bill Lexington | 1 |
| Bridgit Mendler | Ashley Wilkenson | 1 |
| Jeananne Goossen | Vita Martin (voice) | 1 |
| Michael Strahan | Himself | 1 |
| Kesha | Kesha | 1 |
| Josh Coxx | Wade Cole (as Josh Coxx) | 1 |
| Kelly Ripa | Herself | 1 |
| Caitlin Carver | Juliette's Dancer | 1 |
| Scott Reeves | Noel Laughlin | 1 |
| Sylvia Jefferies | Jolene Barnes | 1 |
| Christian James | Dan | 1 |
| Greyson Chadwick | Flight Attendant | 1 |
| Jon Menick | Mr. Mason | 1 |
| Joseph David-Jones | Clay | 1 |
| Joshua Childs | Carpenter | 1 |
| Myles Moore | Jake Maitland | 1 |