| Name | Character | Episodes |
|---|---|---|
| Jennifer Tilly | Crystal | 22 |
| Stockard Channing | Dr. Lydia Barnes | 22 |
| Ty Burrell | Dr. Oliver Barnes | 22 |
| Christopher Gorham | Benjamin Barnes | 22 |
| Paula Marshall | Dr. Regina Barnes | 22 |
| Henry Winkler | Dr. Stewart Barnes | 22 |
| Jann Carl | 2 | |
| Kaitlin Olson | 1 | |
| Annie Wersching | 1 | |
| Krista Allen | 1 | |
| Wendie Malick | 1 | |
| Erinn Bartlett | 1 | |
| Kimberly Oja | 1 | |
| Suzanne Cryer | 1 | |
| Marion Ross | 1 | |
| Jennifer O'Dell | 1 | |
| Catherine Oxenberg | 1 | |
| Kevin Daniels | 1 | |
| Kristin Richardson | 1 | |
| Barry Bostwick | 1 | |
| Kristen Miller | 1 | |
| Steven Gilborn | 1 | |
| James Naughton | 1 | |
| Terri Hoyos | 1 | |
| Valerie Mahaffey | 1 | |
| Lisa Banes | 1 | |
| Elena Lyons | 1 | |
| Kate Levering | 1 | |
| Andrea Bogart | 1 | |
| Jill Latiano Howerton | Wendy | 1 |
| E.J. Callahan | 1 | |
| Nadia Bjorlin | 1 | |
| Julian Stone | 1 | |
| Valerie Curtin | 1 | |
| Ethel Ayler | 1 | |
| Bruce Wright | 1 | |
| Stephanie Faracy | 1 | |
| Maitland Ward | 1 |