| Becker is a dedicated, outspoken and talented doctor with a gruff exterior. While he tends to offend those who try to get close to him, he is extremely dedicated to his medical practice in the Bronx, N.Y., where he always goes the extra mile to help those in need. But Dr. John Becker looks at the world around him and sees a society gone mad, full of incongruities and just plain wrong thinking. And he has no qualms about saying anything that comes to mind – anything. |
| Name | Character | Episodes |
|---|---|---|
| Ted Danson | Dr. John Becker | 129 |
| Hattie Winston | Margaret Wyborn | 129 |
| Alex Désert | Jake Malinak | 129 |
| Shawnee Smith | Linda | 129 |
| Saverio Guerra | Bob | 116 |
| Terry Farrell | Regina "Reggie" Kostas | 94 |
| Nancy Travis | Chris Connor | 36 |
| Jorge Garcia | Hector Lopez | 13 |
| Frances Fisher | Dr. Elizabeth Carson | 5 |
| Marvin Kaplan | Mr. Gordon | 4 |
| Kenneth Mars | Melvin | 3 |
| Connie Sawyer | Mrs. Yudelson | 3 |
| Elya Baskin | Alexei | 3 |
| Annie Wood | Theresa Campbell | 3 |
| Jason Sklar | Donnie | 2 |
| Judyann Elder | Judge Miriam Reinhold | 2 |
| James Pickens Jr. | Cliff | 2 |
| Molly Hagan | Sara | 2 |
| French Stewart | Jim / Jerry / Stephanie | 2 |
| Danny Woodburn | Arnoldo | 2 |
| Mariel Hemingway | Ruth Saunders | 2 |
| Davenia McFadden | Annette Johnson | 2 |
| Sara Mornell | Anita | 2 |
| Randy Sklar | Ricky | 2 |
| Derek Basco | Jimmy | 2 |
| Kevin James | Doug Heffernan (uncredited) | 1 |
| Mary Steenburgen | Patient (uncredited) | 1 |
| Lauren Holly | Laura | 1 |
| Octavia Spencer | Ticket Woman | 1 |
| Paul Bates | Mr. Garland | 1 |
| John DiMaggio | Mr. Thalasinos | 1 |
| Conchata Ferrell | Zora | 1 |
| Dick Van Dyke | Fred Becker | 1 |
| Jaime Pressly | Grace | 1 |
| Wade Williams | George | 1 |
| Jon Cryer | Roger | 1 |
| Richard Schiff | Berry Becker | 1 |
| John Astin | Richard Wilson | 1 |
| Dave Foley | Owen | 1 |
| Victor Webster | 1 | |
| Kali Rocha | Kayla | 1 |
| Mitzi McCall | Mrs. Gould | 1 |
| Frank Roman | Mr. Danzetti | 1 |
| Taylor Nichols | Marty | 1 |
| Kyle Massey | Kid | 1 |
| Jacob Smith | Jared | 1 |
| Orson Bean | Mr. Bennett | 1 |
| Hal Holbrook | Mr. Humphries | 1 |
| Leon Russom | Fire Marshal | 1 |
| Robert Joy | Tetzloff | 1 |
| T.J. Thyne | Mr. Messinger | 1 |
| Betty Garrett | Mrs. Firth | 1 |
| Miriam Shor | Rosie, DMV Employee | 1 |
| Alice Krige | Dr. Sondra Rush | 1 |
| Nicollette Sheridan | Anna | 1 |
| George Wendt | Frank | 1 |
| Tamara Taylor | Dana McCall | 1 |
| Yeardley Smith | Ruby | 1 |
| Carol Ann Susi | Mrs. Marino | 1 |
| Jim Rash | Eddie Blatt | 1 |
| David Graf | Lloyd Martin | 1 |
| Lindsay Price | Amanda | 1 |
| Kathleen Freeman | Edith / Evelyn | 1 |
| John Rubinstein | Dickie | 1 |
| Rhea Perlman | Dr. Katherine Simmons | 1 |
| Lin Shaye | Mrs. Cooper | 1 |
| David Chisum | Good Looking Guy | 1 |
| Daran Norris | Man | 1 |
| Molly Cheek | Donna | 1 |
| Gilbert Gottfried | Alan | 1 |
| Matt Battaglia | Lester | 1 |
| LeVar Burton | Mr. Haller | 1 |
| Heidi Swedberg | Mrs. Whitford | 1 |
| Travis T. Flory | Kid | 1 |
| Anne Pitoniak | Tillie | 1 |
| Ken Davitian | Cab Driver (uncredited) | 1 |
| Jolie Jenkins | Lisa | 1 |
| Paul Dooley | Mr. Lerner | 1 |
| Michael J. Pollard | Elliott | 1 |
| Jason Kravits | Mr. Whitford | 1 |
| Jackie Debatin | Rita | 1 |
| Dan Martin | 1 | |
| Regis Philbin | Homeless Man | 1 |
| Jim Ward | Dr. Regozy | 1 |
| Abigail Mavity | Abigail | 1 |
| Joe Nieves | Joe | 1 |
| Josh Blake | Danny Grillo | 1 |
| Jon Polito | Leonard Nagle | 1 |
| Leonard Nimoy | Professor Emmett Fowler | 1 |
| J.P. Manoux | Rusty | 1 |
| Kenneth Choi | Kim Nam Kyu | 1 |
| Keith Szarabajka | Wayne | 1 |
| Bill Cosby | Hilton Lucas (uncredited) | 1 |
| Sean O'Bryan | Randy | 1 |
| Dyllan Christopher | Sean | 1 |
| Kyla Pratt | Keisha | 1 |
| Amy Farrington | Judy | 1 |
| John Mahoney | Father Joe D'Andrea | 1 |
| Andy Milder | Clark | 1 |
| Lombardo Boyar | Hector | 1 |
| Dave Power | Jerry | 1 |
| Sean Marquette | Jimmy | 1 |
| Jenica Bergere | Connie | 1 |
| Denise Dowse | Janet Katz | 1 |
| James DuMont | Mr. Rigney | 1 |
| Mary Mara | Beth | 1 |
| Nathan Davis | Milton Fowler | 1 |
| Bruce Gray | Mr. Fuller | 1 |
| Frank Novak | Myers | 1 |
| Stephen Lee | Mr. Herrup | 1 |
| Gregg Berger | Clerk | 1 |
| Kathy Christopherson | Gina | 1 |
| James Read | Dan | 1 |
| John Fugelsang | Greg Jackson | 1 |
| Kara Zediker | Debbie | 1 |
| Smith Cho | Victoria | 1 |
| Peter Siragusa | Mr. Marino | 1 |
| Jon Wellner | Graduate #2 | 1 |
| Michael Bower | Patient | 1 |
| Richard Gilliland | Frank | 1 |
| Esther Scott | Marge | 1 |
| Lauri Hendler | Mrs. Howarth | 1 |
| Valerie Curtin | Ms. Russell | 1 |
| Scott Thompson Baker | Dr. Witlin | 1 |
| Earl Billings | Mr. Kimsey | 1 |
| Mary-Pat Green | Denise | 1 |
| Camille Saviola | Mrs. Corigliani | 1 |
| Claire Yarlett | Ms. Alcott | 1 |
| Wayne Alexander | Wholesome Man | 1 |
| Ken Thorley | Patient #1 | 1 |
| John Harrington Bland | Nervous Patient | 1 |
| Lauri Johnson | Mrs. Sullivan | 1 |
| Jessica Sara | Little Girl | 1 |
| Joe O'Connor | Mr. Engel | 1 |
| Chip Heller | Customer | 1 |
| Jenny Gago | Mrs. Cruz | 1 |
| Gregory White | Monsignor | 1 |
| Kitty Swink | Helen Willakie | 1 |
| Annie Abbott | Mrs. Vale | 1 |
| Thom Gossom Jr. | Mr. Rainey | 1 |
| Clayton Landey | Mr. Morello | 1 |
| Arturo Gil | Water Man | 1 |
| Betty Murphy | Mrs. Katz | 1 |
| James Wellington | Man #2 | 1 |
| Lauren Tuerk | Patient | 1 |
| Zachary Isaiah Williams | Kid #1 | 1 |
| Jesse D. Goins | Locksmith | 1 |
| Amy Spanger | Susan | 1 |
| Shannon Welles | Mrs. Soloman | 1 |
| Darryl Theirse | Henry Millman | 1 |
| R. Martin Klein | Husband | 1 |
| Vasili Bogazianos | Dr. Axelrod | 1 |
| Floyd Van Buskirk | Delivery Guy | 1 |
| Loren Berman | Scott | 1 |
| Jimmy Pardo | Mr. Ford | 1 |
| Melba Englander | Nurse | 1 |
| Kathryn Joosten | Mrs. Goldsmith | 1 |
| Cleo King | Mrs. Davis | 1 |
| Bruce A. Young | Officer Matlin | 1 |
| Aaron Fors | 1 | |
| Cody Arens | Boy | 1 |
| Logan O'Brien | Billy | 1 |
| Chris Warren | 1 | |
| Antonio Sabàto, Jr. | Linda's Boyfriend | 1 |
| Julie Caitlin Brown | Nicky | 1 |