| Name | Character | Episodes |
|---|---|---|
| Lin-Manuel Miranda | Dr. Ruben Marcado | 13 |
| Alana de la Garza | Dr. Lena Solis | 13 |
| John Carroll Lynch | Will Hayes | 13 |
| Phylicia Rashād | Dr. Vanessa Young | 13 |
| Ruta Gedmintas | Olivia Flynn | 13 |
| Steven Pasquale | Dr. Jason Cole / Ian Price | 13 |
| Michael Esper | Dr. Kenneth Jordan | 13 |
| Jurnee Smollett | Abby Young | 2 |