| When Jessica Drew was bitten by a poisonous spider as a child, her father saved her life by injecting her with an experimental "spider serum," which also granted her superhuman powers. As an adult, Jessica works as editor of Justice Magazine but when trouble arises, Jessica slips away to change into her secret identity of Spider-Woman. |
| Name | Character | Episodes |
|---|---|---|
| Joan Van Ark | Spider-Woman / Jessica Drew (voice) | 16 |
| Dick Tufeld | Narrator (voice) | 16 |
| Vic Perrin | Kuthu (voice) | 16 |
| Larry Carroll | Detective Miller (voice) | 16 |
| Bryan Scott | Billy (voice) | 16 |
| Paul Soles | Spider-man (voice) | 2 |