| Name | Character | Episodes |
|---|---|---|
| Chris Walker | Rob Hollins | 2470 |
| Bill Rodgers | Eddie Slade | 2442 |
| Jan Pearson | Karen Hollins | 2442 |
| Seán Gleeson | Ronnie Woodson | 2442 |
| Ariyon Bakare | Dr. Ben Kwarme | 2440 |
| Anita Carey | 2440 | |
| Christopher Timothy | 2440 | |
| Robert Cavanah | Dr. Peter Kendrick | 2440 |
| Jessica Turner | 2440 | |
| Owen Brenman | Heston Carter | 2440 |
| Tom Butcher | Dr. Marc Eliot | 2440 |
| Dido Miles | 2440 | |
| Martha Howe-Douglas | 2440 | |
| Diane Keen | 2440 | |
| Lu Corfield | Freya Wilson | 2440 |
| Michael McKell | Dr. Nick West | 2440 |
| Matthew Chambers | Daniel Granger | 2440 |
| Daniel Anthony | Lex Keavey | 2440 |
| Elisabeth Dermot Walsh | Zara Carmichael | 2238 |
| Ian Midlane | Al Haskey | 1804 |
| Stirling Gallacher | George Woodson | 1422 |
| Ian Midlane | 753 | |
| Simona Zivkovska | Julie Keane | 187 |
| John Lightbody | 119 | |
| Sam Heughan | Scott Neilson | 20 |
| Leanne Wilson | 19 | |
| Chaneil Kular | Tariq Amiri | 12 |
| Scott Adkins | Ross | 3 |
| Catherine Hannay | AJ Hawley | 3 |
| Brian Cant | Derek Richmond | 2 |
| Elisabeth Hopper | Lizzie | 2 |
| Beatriz Romilly | Maria Domingues | 2 |
| Emilia Clarke | Saskia Mayer | 1 |
| Jack O'Connell | Connor Yates | 1 |
| Sally Hawkins | Sarah Carne | 1 |
| Natalia Tena | 1 | |
| Simone Ashley | Sofia Johal | 1 |
| Laura Howard | Jane Taylor | 1 |
| Laura Howard | Zoe Durand | 1 |
| Laura Howard | Amy Dobson | 1 |
| Graham McTavish | Paul Brookes | 1 |
| Ewan Mitchell | Genyen | 1 |
| Ed Westwick | Holden Edwards | 1 |
| Nina Sosanya | Jasmine | 1 |
| Toyah Willcox | Marcy Preston | 1 |
| Emmanuel Imani | Jonas Lusala | 1 |
| Emmanuel Imani | Seth Bonolo | 1 |
| Vicky McClure | Kirsty Dunns | 1 |
| Peter Sallis | Arthur Weatherill | 1 |
| Will Tudor | Young Sam | 1 |
| Alana Boden | Lucy Whiteside | 1 |
| Ian Brimble | James Purdey | 1 |
| Letitia Dean | 1 | |
| Scarlett Hefner | 1 | |
| Samantha Power | 1 | |
| Honor Blackman | Rachel Knott | 1 |
| Pearl Mackie | Anne-Marie Frasier | 1 |
| Olivia Swann | Karinna Hailes | 1 |
| Joe Dempsie | Lee Lindsay | 1 |
| Sheridan Smith | Claire | 1 |
| Callum Blue | Denny | 1 |
| Lucy Davis | Nicky Andrews | 1 |
| Ryan Cartwright | Henry Lincoln | 1 |
| Rosalie Craig | Shona King | 1 |
| Alice Henley | Sophie Treadwell | 1 |
| Alice Henley | Bella Bentley | 1 |
| Alice Henley | Tallulah Walsh | 1 |
| Ed Byrne | 1 | |
| James Warrior | Martin Blackburn | 1 |
| James Warrior | Jim Clarke | 1 |
| Rosemary Leach | Meg Carpenter | 1 |
| Anneika Rose | Priya Kaur Banga | 1 |
| Jonathan Howard | Luke Neville | 1 |
| Kevin Bishop | Craig Prentice | 1 |
| Nicola Bryant | Jackie Fallon | 1 |
| Nicola Bryant | Sonia Heyward-Smith | 1 |
| Amaka Okafor | Brianna Quinn | 1 |
| Amaka Okafor | Petra Keane | 1 |
| Laura Swift | Jen Banks | 1 |
| David Murray | Jez Clifton | 1 |
| Brad Gorton | Nick Merriweather | 1 |
| Nico Mirallegro | Giovanni Mannasori | 1 |
| Luke Ward-Wilkinson | Alex Kennedy | 1 |
| Shauna Shim | Joanna Parks | 1 |
| Philip Whitchurch | 1 | |
| Wim Snape | Josh Hammer | 1 |
| Les Dennis | Charles Lee | 1 |
| Rochelle Neil | Laura Garson | 1 |
| Rochelle Neil | Kelly Abraham | 1 |
| Adrianna Bertola | Gemma Branscombe | 1 |
| Adam Paul Harvey | Duncan Medcalf | 1 |
| Hywel Simons | Dave Perrin | 1 |
| Hywel Simons | Major Simon Fallon | 1 |
| Margaret John | 1 | |
| Pooky Quesnel | Angela Crowther | 1 |
| Rob Ostlere | Graham Trist | 1 |
| Rob Ostlere | Ashley Hughes | 1 |
| Rose Reynolds | Paula Abbot | 1 |
| Richard Walsh | Trevor Farrell | 1 |
| Richard Walsh | Richard Moore | 1 |
| Cassidy Little | Edward Rourke | 1 |
| Cassidy Little | Frank Thorpe | 1 |
| Tom Hudson | Leo Jones | 1 |
| Beatriz Romilly | Maria Escobar | 1 |
| Amy Noble | Barbara Edwards | 1 |
| Amy Noble | Beth Flanders | 1 |
| Nicholas Courtney | 1 | |
| Ruth Madoc | Jean March | 1 |
| Ruth Madoc | Alice Swanson | 1 |
| Mary Tamm | 1 | |
| Sian Reeves | Fiona Dow | 1 |
| Mica Ricketts | Selina Barnett | 1 |
| Alexander Morris | Leyton Haines | 1 |
| Rukku Nahar | Rana Khan | 1 |
| Ben Silverstone | Joe Nyland | 1 |
| Dinita Gohil | Penny Glover | 1 |
| Lucy Drive | Chloe Moulton | 1 |
| Katie Sheridan | Ellie Richards | 1 |
| Alex Felton | Rupert Barnes | 1 |
| Alex Felton | Tom Waverley | 1 |
| Ryan Hawley | Jeremy Evesham | 1 |
| Stuart McGugan | 1 | |
| Sandy Walsh | Mrs. Conway | 1 |
| Sandy Walsh | Andrea Davenport | 1 |
| Fabienne Piolini-Castle | Kim Withers | 1 |
| Fabienne Piolini-Castle | Rose Griffin | 1 |
| Peter Baldwin | Tom | 1 |
| Peter Baldwin | Dougie Carmichael | 1 |
| Simon Delaney | Toby Gill | 1 |
| Tat Whalley | Nick Lindsay | 1 |
| Florence Kosky | Anna Mason-Lewis | 1 |
| Tom Clegg | Jamie Carvell | 1 |
| Tom Clegg | Tom Bradshaw | 1 |