| Name | Character | Episodes |
|---|---|---|
| John Goodman | Senator Gil John Biggs | 21 |
| Julie White | Maddie Biggs | 21 |
| Yara Martinez | Adriana de Portago | 21 |
| Mark Consuelos | Senator Andy Guzman | 21 |
| Clark Johnson | Senator Robert Bettencourt | 21 |
| Matt Malloy | Senator Louis Laffer | 21 |
| Brooke Bloom | Julie Carrell | 18 |
| Kobi Libii | Aaron Stimson | 16 |
| Natalie Gold | Katherine Sims | 15 |
| Wanda Sykes | Senator Rosalyn DuPeche | 14 |
| Amy Sedaris | Louise Laffer | 14 |
| Willa Fitzgerald | Lola Laffer | 12 |
| Haley Joel Osment | Shelby Mellman | 12 |
| Richard Cox | Graydon Talbot | 10 |
| Cynthia Nixon | Senator Carly Armiston | 6 |
| Tony Plana | Benito 'Benny' Lopez | 6 |
| Matthew Humphreys | Colonel Leland Grimmel | 6 |
| Penn Jillette | Penn Jillette | 5 |
| Lucy DeVito | Charity Robeson | 4 |
| Todd Susman | Saul Watt | 4 |
| Janel Moloney | Senator Peg Stanchion | 4 |
| Molly Bernard | Angie Sullivan | 4 |
| Kate Jennings Grant | Courtney Townsend | 4 |
| Marylouise Burke | Betty Mower | 4 |
| Lee Wilkof | Shelly Watt | 4 |
| Bill Murray | Senator Vernon Smits | 3 |
| Lee Tergesen | Colonel Eugene Drake | 3 |
| Abigail Marlowe | Connie Wyman | 3 |
| Ted King | Al Hickok | 3 |
| Owen Campbell | Dilly DeSantis | 3 |
| Tamara Tunie | Eve Simone-Lewis | 2 |
| Bob Balaban | Senator Elliot Robeson | 2 |
| Chris Matthews | Chris Matthews | 2 |
| Chance Kelly | Bo Carthage, CEO | 2 |
| Wendy Makkena | Molly P. Andreson | 2 |
| Tracy Howe | Colonel Wozniak | 2 |
| Matt Lauer | Self | 2 |
| Jonathan Fried | Counsel | 2 |
| Matty Blake | Captain Brandon Carshaw, Ret. | 2 |
| Bret Lada | Sgt. Mel Axelrod | 2 |
| Fenton Lawless | Audience Member | 1 |
| Sharrieff Pugh | Rodney Banaszak | 1 |
| Shae D'Lyn | April Mandela | 1 |
| Bradley Whitford | Senator (Ned) | 1 |
| Bruce Altman | Marty Corman | 1 |
| Matt Servitto | Dan Cipriania-Maloney | 1 |
| Michael Strahan | Self | 1 |
| Florence Faivre | Teata Takaria | 1 |
| Alex Hernandez | Soldier | 1 |
| Amy Rutberg | Melanie Saks | 1 |
| Jenn Harris | Maggie | 1 |
| Steven Hauck | Dr. Albert Hydell | 1 |
| Elizabeth Warren | Elizabeth Warren | 1 |
| Tommy Walker | Soldier | 1 |
| Kelly Ripa | Self | 1 |
| Lanny Flaherty | Man | 1 |
| Josh Pais | Owen Lefkowitz | 1 |
| Frank Deal | Teddy Bungemack | 1 |
| Jack Gilpin | Senate Chaplain Teeter | 1 |
| Charles Techman | Waiter | 1 |
| Rachel Maddow | Rachel Maddow | 1 |
| Wolf Blitzer | Wolf Blitzer | 1 |
| Frederick Weller | Digger Mancusi | 1 |
| Chuck Schumer | Chuck Schumer | 1 |
| Andy Powers | Matthias | 1 |
| Frank Ridley | Agribusiness Guy | 1 |
| Jason Furlani | Officer (Miller) | 1 |
| Andre Ware | Sales Clerk | 1 |
| Andy Cohen | Andy Cohen | 1 |
| Nick Gregory | Grant Feininger | 1 |
| Roscoe Orman | Randall | 1 |
| Jake Robards | David | 1 |
| John Harrington Bland | Agribusiness Guy | 1 |
| Ptolemy Slocum | Jeff | 1 |
| Venida Evans | Parishioner | 1 |
| Robert Stanton | Van Pingree | 1 |
| Justin Lord | Reverend Mike | 1 |
| Donna Hanover | Senator | 1 |
| Sydni Beaudoin | Elise Gittleson | 1 |
| Kevin Geer | Normal Chase | 1 |
| Johanna Day | Woman | 1 |
| Erin Gann | Dylan Mayfair | 1 |
| Tamara Torres | Corinne | 1 |
| John Keating | Edward Grottlemeyer | 1 |
| Holly Curran | Becky Dorphan | 1 |
| Jeff Kim | Young Soo | 1 |
| Cadden Jones | Reporter | 1 |
| Sue Jean Kim | Helen Binkowski | 1 |
| Robert Ray Manning Jr. | Conceirge | 1 |
| Todd Alan Crain | Host | 1 |
| Simon Feil | Bob - The Reporter | 1 |
| Pamela Stewart | Show Guest | 1 |
| Jimmy Gary Jr. | Police Commander | 1 |
| Rick Crom | Man | 1 |
| Christine Lin | Reporter | 1 |
| Amelia Campbell | Sue | 1 |