| The series initially starred veteran movie supporting actor Ward Bond as the wagon master, later replaced upon his death by John McIntire, and Robert Horton as the scout, subsequently replaced by lookalike Robert Fuller a year after Horton had decided to leave the series. The series was inspired by the 1950 film Wagon Master directed by John Ford and starring Ben Johnson, Harry Carey Jr. and Ward Bond, and harkens back to the early widescreen wagon train epic The Big Trail starring John Wayne and featuring Bond in his first major screen appearance playing a supporting role. Horton's buckskin outfit as the scout in the first season of the television series resembles Wayne's, who also played the wagon train's scout in the earlier film. |
| Name | Character | Episodes |
|---|---|---|
| Frank McGrath | Charlie Wooster | 284 |
| Terry Wilson | Bill Hawks | 284 |
| Robert Horton | Flint McCullough | 189 |
| Ward Bond | Major Seth Adams | 152 |
| John McIntire | Christopher Hale | 139 |
| Denny Miller | Duke Shannon | 113 |
| Robert Fuller | Cooper Smith | 64 |
| Michael Burns | Barnaby West | 27 |
| Ernest Borgnine | Willy Moran | 2 |
| Mickey Rooney | Samuel T. Evans | 2 |
| Ellen Corby | Aunt Em | 2 |
| Chick Hannan | Wagon Train Member | 2 |
| Leslie Nielsen | Brian Conlin | 1 |
| Bruce Dern | Wilkins | 1 |
| Bruce Dern | Jud Fisher | 1 |
| Tom Skerritt | Hamish Browne | 1 |
| Peter Falk | Gus Morgan | 1 |
| John Wayne | Gen. William Tecumseh Sherman | 1 |
| Suzanne Pleshette | Myra Marshall | 1 |
| Katharine Ross | Bonnie Brooke | 1 |
| Ernest Borgnine | Indian Brave (uncredited) | 1 |
| Ernest Borgnine | Earl Packer | 1 |
| Ernest Borgnine | Estaban Zamora | 1 |
| Edgar Buchanan | Ben Mattox | 1 |
| Ken Curtis | Kyle Cleatus | 1 |
| Ken Curtis | Pappy Lightfoot | 1 |
| Harold J. Stone | Mayor Tucker | 1 |
| Dan Duryea | Amos | 1 |
| Morgan Jones | Jason Elliott | 1 |
| Andrew Duggan | Dan Brady | 1 |
| Stacy Harris | Sheriff Francher | 1 |
| Stacy Harris | Sheriff | 1 |
| Stacy Harris | The Sheriff | 1 |
| Robert Osterloh | Ransome Jarvis | 1 |
| Robert Osterloh | Wilbur Martin | 1 |
| Michael Forest | Julio | 1 |
| Mary Field | Mrs. Gillespie | 1 |
| Nancy Gates | Della | 1 |
| Norman Leavitt | Sam the Bartender | 1 |
| Norman Leavitt | Wagon Train Member | 1 |
| Norman Leavitt | Mr. Kelsey | 1 |
| Norman Leavitt | Cory (uncredited) | 1 |
| Norman Leavitt | Slim | 1 |
| Fred Graham | The Bartender | 1 |
| Arthur Shields | Judge Tremayne | 1 |
| Marjorie Main | Cassie Tanner | 1 |
| Robert Pine | Jonathan Olsen | 1 |
| Lee Marvin | Jud Benedict | 1 |
| Lee Marvin | Jose Morales | 1 |
| Carolyn Jones | Molly Kincaid | 1 |
| Jane Wyman | Dr. Carol Ames Willoughby | 1 |
| Jane Wyman | Hannah Barber | 1 |
| Dean Stockwell | Jimmy Drew | 1 |
| Dean Stockwell | Juan Ortega | 1 |
| Dean Stockwell | Rodney Lawrence | 1 |
| Dean Stockwell | Will Santee | 1 |
| Barbara Bain | Lucy Garrison | 1 |
| Grant Withers | Mark Hammond | 1 |
| Peter Fonda | Orly French | 1 |
| L.Q. Jones | Lenny | 1 |
| William Smith | Thomas Lance | 1 |
| Lon Chaney Jr. | Louis Roque | 1 |
| Lon Chaney Jr. | Carstairs | 1 |
| Lee Van Cleef | Rufe Beal | 1 |
| Richard Jaeckel | Barker | 1 |
| Cloris Leachman | Loretta | 1 |
| Clu Gulager | Harry Diel | 1 |
| Virginia Gregg | Grace Lowe | 1 |
| Virginia Gregg | Miss Roberts | 1 |
| Dick Miller | Michel | 1 |
| Forrest Tucker | Rex Montana | 1 |
| Rory Calhoun | Jarbo Pierce | 1 |
| Bill Mumy | Toddy | 1 |
| Shelley Winters | Ruth Owens | 1 |
| Michael Ansara | Chief North Star | 1 |
| Michael Ansara | Adam MacKenzie | 1 |
| John Carradine | Park Cleatus | 1 |
| J. Pat O'Malley | Colin Dunn | 1 |
| J. Pat O'Malley | Earl Caulkins | 1 |
| Johnny Crawford | Jimmy Bennett | 1 |
| Martin Milner | Matt Trumbell | 1 |
| Agnes Moorehead | Mary Halstead | 1 |
| Paul Fix | Jake | 1 |
| Paul Fix | Amos Billings | 1 |
| Paul Fix | Sean Bannon | 1 |
| Willis Bouchey | Mr. Grant | 1 |
| Jay North | Tom Blake | 1 |
| Ross Martin | Sam Pulaski | 1 |
| Paul E. Burns | Fred Elkins | 1 |
| Jean Allison | Angela Kingdom | 1 |
| Wally Cox | Vincent Eaglewood | 1 |
| Warren Oates | Private Silas Carpenter | 1 |
| Henry Brandon | Chief Dark Eagle | 1 |
| Henry Brandon | Black Panther | 1 |
| Henry Brandon | Ute Indian Chief | 1 |
| Harry Carey, Jr. | Charlie Hankins | 1 |
| Harry Carey, Jr. | John Jay Burroughs | 1 |
| Lee Patrick | Mrs. Elliot Swinbourne Steele | 1 |
| Alan Hale Jr. | Kirby | 1 |
| Charles Drake | Marshal Vern Rothman | 1 |
| Hari Rhodes | Jefferson Washington Freeman | 1 |
| John Doucette | Marshal Jason Hartman | 1 |
| John Doucette | Michael McGoo | 1 |
| John Doucette | Ben Engel | 1 |
| John Doucette | Burt Enders | 1 |
| John Doucette | Gen. Jameson | 1 |
| John Doucette | Col. Wayne Lathrop | 1 |
| John Doucette | Chandler Ames | 1 |
| John Doucette | Boone Gilla | 1 |
| Polly Bergen | Kitty Allbright | 1 |
| Rhonda Fleming | Jennifer Churchill | 1 |
| Rhonda Fleming | Patience Miller | 1 |
| John Ericson | 1 | |
| Carleton Young | Dr. Colter Craven | 1 |
| Ray Teal | Ray Tarback | 1 |
| William Demarest | Mr. Hennessey | 1 |
| Jack Kelly | Fenton Canaby | 1 |
| H.M. Wynant | Clay Boudreau | 1 |
| H.M. Wynant | Bart Haskell | 1 |
| Noah Beery Jr. | Stump Beasley | 1 |
| Anna Lee | Mrs. Allyris Craven | 1 |
| Marjorie Bennett | Sylvester's Wife | 1 |
| Marjorie Bennett | Maud Wilks | 1 |
| Seymour Cassel | Ed | 1 |
| John Larch | John Ramsey | 1 |
| Rand Brooks | Thomas Pope | 1 |
| Ed Wynn | Cappy Darrin | 1 |
| Russell Thorson | Warden | 1 |
| Russell Thorson | Major | 1 |
| Russell Thorson | Simon Landis | 1 |
| Claire Carleton | Depot Clerk | 1 |
| Marshall Thompson | Bradley Mason | 1 |
| Marshall Thompson | Will Stebbins | 1 |
| Laurie Mitchell | June | 1 |
| Laurie Mitchell | Annie Tolleson | 1 |
| Milton Frome | Tom Yates | 1 |
| Milton Frome | Sheriff | 1 |
| Lane Bradford | Kenny Stark (uncredited) | 1 |
| Harlan Warde | Dr. Haines | 1 |
| Dayton Lummis | Dr. Baldwin | 1 |
| Dayton Lummis | Major P.S. Barham | 1 |
| Dayton Lummis | Rev. Philip Marshall | 1 |
| Perry Cook | The Sheriff | 1 |
| Marc Lawrence | First Mate Ferris | 1 |
| Raymond Bailey | Jim Brenton | 1 |
| Robert Blake | Johnny Kamen | 1 |
| Douglas Fowley | Ed Graham | 1 |
| Paul Birch | Gen. Ulysses Simpson 'Sam' Grant | 1 |
| Paul Birch | Sam Benson | 1 |
| John Harmon | Fabor | 1 |
| Denver Pyle | Bragg | 1 |
| Brandon De Wilde | Daniel Morgan Benedict III | 1 |
| Brandon De Wilde | Mark Miner | 1 |
| Bette Davis | Ella Lindstrom | 1 |
| Robert Fuller | James Fitzpatrick | 1 |
| Leonard Nimoy | Bernabe Zamora | 1 |
| Buck Taylor | Skeeter Ames | 1 |
| Margaret O'Brien | Julie Revere | 1 |
| Vera Miles | Sister Rita | 1 |
| Vera Miles | Janice Stuart | 1 |
| Jeanette Nolan | Chottsie Gubenheimer | 1 |
| Andrew Prine | Eric Camden | 1 |
| Andrew Prine | Felix Colton | 1 |
| Darby Hinton | Benjie Diel | 1 |
| Robert J. Wilke | Sgt. Wick | 1 |
| Robert J. Wilke | Wesley Thomas | 1 |
| Robert J. Wilke | Col. Thomas Stone | 1 |
| Robert J. Wilke | Jabez Moore | 1 |
| Edward Binns | Sheriff Bill Strode | 1 |
| Edward Binns | Jud Steele | 1 |
| Ryan O'Neal | Paul Phillips | 1 |
| John Lupton | Ernie Weaver | 1 |
| Frank De Kova | Obuki | 1 |
| Frank De Kova | Isaiah Quickfox | 1 |
| Frank De Kova | Ocheo | 1 |
| Lola Albright | Leonora Parkman | 1 |
| Read Morgan | Ben Denike | 1 |
| Read Morgan | Curly Horse | 1 |
| Read Morgan | Jake | 1 |
| Richard Bakalyan | Muscles | 1 |
| John Daheim | Wilkins | 1 |
| John Daheim | Corey | 1 |
| Henry Daniell | Morton W. Snipple | 1 |
| William Bendix | Capt. Matthew Cobb | 1 |
| Hank Worden | Hank | 1 |
| Chuck Hayward | Quentin Cleatus | 1 |
| Scotty Morrow | Professor | 1 |
| Frank Ferguson | Judge Hiram Larkin | 1 |
| Tom Simcox | Adam Pierce | 1 |
| Annette Funicello | Rose Pulaski | 1 |
| Joe Turkel | Eddie | 1 |
| Anne Helm | Ruth Cain | 1 |
| Naomi Stevens | Hannah Moses | 1 |
| Danny Borzage | Soldier | 1 |
| Hugh Beaumont | Jed Halick | 1 |
| Amzie Strickland | Arletta Hoag | 1 |
| Kathryn Card | Abby | 1 |
| Kathryn Card | Mrs. Mercer | 1 |
| Arthur Franz | Nathan Forge | 1 |
| Arthur Franz | Dan Highet | 1 |
| Verna Felton | Gran Jennings | 1 |
| Phillip Pine | Manuel Zamora | 1 |
| Alan Marshal | Bart Grover | 1 |
| Alvy Moore | Private Bledsoe | 1 |
| Ann Blyth | Eve Newhope | 1 |
| Ann Blyth | Nancy Winters | 1 |
| Ann Blyth | Martha Barham | 1 |
| Walter Reed | Major Harrison | 1 |
| Walter Reed | Sheriff Miller (uncredited) | 1 |
| Walter Reed | Simms | 1 |
| Frank Overton | Martin Jennings | 1 |
| Frank Overton | The Doctor | 1 |
| Kermit Maynard | Wagon Train Member | 1 |
| Onslow Stevens | Col. Daniel Morgan Benedict II | 1 |
| Onslow Stevens | Jack Hanford | 1 |
| Sharon Farrell | Judy Wilson | 1 |
| Sharon Farrell | Pearlie Garnet | 1 |
| Byron Foulger | Jervis Clinton | 1 |
| Byron Foulger | Hibbs | 1 |
| Byron Foulger | Humphrey Pumphret | 1 |
| Byron Foulger | George Duskin | 1 |
| Peter Mamakos | Chief (uncredited) | 1 |
| Myrna Fahey | Melanie Craig | 1 |
| Myrna Fahey | Jane Hawkins | 1 |
| Dal McKennon | Lee | 1 |
| Dal McKennon | Alex | 1 |
| Dal McKennon | The Horsetrader | 1 |
| Lynn Loring | Kathy Jennings | 1 |
| Joseph Vitale | Chenwakee | 1 |
| Harry Harvey | Mr. Parsons | 1 |
| Harry Harvey | Vern Orton | 1 |
| Harry Harvey | Sheriff Matt | 1 |
| Harry Harvey | Deputy Marshall Clancy (uncredited) | 1 |
| Harry Harvey | Mayor Ives | 1 |
| Guinn 'Big Boy' Williams | Calvin Bryngelson | 1 |
| King Donovan | Henry Bennett | 1 |
| Joby Baker | Nathan May | 1 |
| Susan Silo | Betty Whittaker | 1 |
| Susan Silo | Susan | 1 |
| Kevin O'Neal | Efraim | 1 |
| John Holland | Ellington | 1 |
| Regis Toomey | Mr. Hunter | 1 |
| Claire Trevor | C.L. Harding | 1 |
| Kevin Hagen | Lansing | 1 |
| Wesley Lau | Stevens | 1 |
| Ron Harper | Lt. Bevins | 1 |
| Dorothy Neumann | Wagon Train Member (uncredited) | 1 |
| Russell Johnson | Craig Manson | 1 |
| Rex Holman | Joe Abbot | 1 |
| Rex Holman | Harry | 1 |
| Rex Holman | Homer | 1 |
| Cyril Delevanti | Jamieson | 1 |
| Dick Wessel | Biff | 1 |
| Johnny Cash | Frank Hoag | 1 |
| Richard Eyer | Matthew Brant | 1 |
| Larry Pennell | Marshal Trace McCloud | 1 |
| Russ Conway | Mr. Freeman (uncredited) | 1 |
| Russ Conway | Mr. McCrea | 1 |
| Damian O'Flynn | Mr. Emerson | 1 |
| Allen Jenkins | Mr. Gillespie | 1 |
| Peter Brown | Benedict O'Brien | 1 |
| Peter Brown | Ben Campbell | 1 |
| Jean Hagen | Maidie Brant | 1 |
| Jean Hagen | Sarah Proctor | 1 |
| John Dennis | Police Sergeant | 1 |
| Virginia Christine | Minna Collins | 1 |
| Virginia Christine | Amanda Santee | 1 |
| Edward Platt | Spinoza de Costa | 1 |
| Lovyss Bradley | Wagon Train Member (uncredited) | 1 |
| Lovyss Bradley | Wagon Train Member | 1 |
| Lovyss Bradley | Mrs. Olsen (uncredited) | 1 |
| Chris Robinson | Brad Proctor | 1 |
| George Gobel | Horace Best | 1 |
| Mae Marsh | Mrs. Jesse Grant | 1 |
| Charles Seel | Wagon Train Member | 1 |
| Charles Seel | Mort | 1 |
| Larry J. Blake | Sheriff (uncredited) | 1 |
| Larry J. Blake | Booley Herbert | 1 |
| Larry J. Blake | Chief White Cloud | 1 |
| Jane Wyatt | Heather Mahoney | 1 |
| Dennis Patrick | Josh Anders | 1 |
| Harvey Stephens | Maxwell Revere | 1 |
| Harvey Stephens | Bank Manager | 1 |
| Alex Gerry | Dr. Vincent Monroe | 1 |
| Jim McMullan | Arnie Swenson | 1 |
| Cliff Lyons | Creel Weatherby | 1 |
| Richard Reeves | Sam Hulsey | 1 |
| Richard Reeves | Roberts | 1 |
| Richard Reeves | The Trapper | 1 |
| Richard Reeves | Pop Harmon | 1 |
| Richard Reeves | Walls | 1 |
| Richard Reeves | Orv Bassett | 1 |
| Richard Reeves | Patrick McClure | 1 |
| Dan Riss | Kelleher | 1 |
| Tom McKee | Vinson | 1 |
| Tom McKee | Archibald McAdoo | 1 |
| Penny Santon | Carlota Perez | 1 |
| George Dunn | Jones | 1 |
| Jim Bannon | Ben Graham | 1 |
| Dick Cherney | Townsman (uncredited) | 1 |
| Robert Emhardt | Papa Kling | 1 |
| Robert Emhardt | Roger Crowell | 1 |
| Dawn Wells | Mrs. Murray | 1 |
| Frank Hagney | Jail Prisoner | 1 |
| Louis Quinn | Trinket Seller | 1 |
| Theodore Newton | Buzz | 1 |
| Randy Boone | David Garner | 1 |
| Joseph Mell | Storekeeper | 1 |
| Joseph Mell | Wheelman | 1 |
| Joseph Mell | Proprietor (uncredited) | 1 |
| Jacqueline deWit | Princess | 1 |
| Marshall Reed | Tom | 1 |
| Marshall Reed | The Sheriff | 1 |
| Tristram Coffin | Whittaker | 1 |
| Art Linkletter | Sam Darland | 1 |
| Ray Montgomery | George | 1 |
| Steven Ritch | Red Cloud | 1 |
| Steven Ritch | Running Bear | 1 |
| Frank J. Scannell | Griff | 1 |
| Dick Rich | Bartender | 1 |
| Rachel Ames | Nora Courtney | 1 |
| Rachel Ames | Florence Yeager | 1 |
| Lynette Bernay | Lynn | 1 |
| Kristine Miller | Milly Clark | 1 |
| William Challee | Homeowner | 1 |
| William Challee | Freighter (uncredited) | 1 |
| Richard H. Cutting | Col. Lollier | 1 |
| Russell Simpson | Mr. Carr | 1 |
| Brenda Scott | Martha Kincaid | 1 |
| Chuck Roberson | Junior | 1 |
| Nancy Reagan | Mrs. Baxter | 1 |
| Paul Sorensen | Posse Member | 1 |
| Herbert Lytton | Dr. Jenner | 1 |
| Herbert Lytton | Doctor | 1 |
| Herbert Lytton | Dr. Porter | 1 |
| Eddy Waller | Ned | 1 |
| Sol Gorss | Townsman (uncredited) | 1 |
| Gail Bonney | Wagon Train Member | 1 |
| Jack Pennick | Drill Sergeant Tim Molloy | 1 |
| Robert Patten | Kermit | 1 |
| Stuart Randall | Sheriff Hixon | 1 |
| Don Grady | George | 1 |
| Mike Steen | Hunting Party Member | 1 |
| Ken Mayer | Jesse | 1 |
| Aline Towne | Meg | 1 |
| Terry Burnham | Marguerite Lindstrom | 1 |
| Fred Sherman | Attendant | 1 |
| Deborah Walley | Nancy Styles | 1 |
| Emerson Treacy | George Hankes | 1 |
| Mauritz Hugo | Frankie Palmer | 1 |
| Mauritz Hugo | Haines | 1 |
| John Rodney | Major Groff | 1 |
| Gary Hunley | Nat Conners | 1 |
| Abel Fernandez | Tonino (uncredited) | 1 |
| Sherwood Price | Jesse | 1 |
| Harry Hickox | Capt. Albert Sanborn | 1 |
| Janice Rule | Maggie Thomas | 1 |
| Arthur Tovey | Townsman | 1 |
| Jay Novello | Carlotti | 1 |
| Phyllis Thaxter | Christine Elliot | 1 |
| Lillian Bronson | Alicia Thorton | 1 |
| Lillian Bronson | Miss Phoebe | 1 |
| Robert Armstrong | Roy Daniels | 1 |
| Robert F. Simon | Jay Thorton | 1 |
| Nancy Rennick | Judith Foster | 1 |
| Nancy Rennick | Mrs. Stevens | 1 |
| Nancy Rennick | Kate Sheffield | 1 |
| Roberta Shore | Millie Allen | 1 |
| Joe Flynn | Edwin Crook | 1 |
| Jean Hale | Susan Durfee | 1 |
| Janis Paige | Nellie Jefferson | 1 |
| Dan Tobin | Mr. Bill Dashwood | 1 |
| Tommy Sands | Ethan Morgan | 1 |
| Tommy Sands | Keith Lance | 1 |
| Tommy Sands | Larry Hanify | 1 |
| Claude Jarman Jr. | Jeremiah Collingwood | 1 |
| Audrey Dalton | Lola Medina | 1 |
| Audrey Dalton | Danna Bannon | 1 |
| Beverly Washburn | Susan Palmer | 1 |
| Kent Smith | Prof. Paul Owens | 1 |
| Mary Treen | Bessie Treymore (uncredited) | 1 |
| George Chandler | Cleveland 'Clee' McMasters | 1 |