| Name | Character | Episodes |
|---|---|---|
| Beatie Edney | Judith Kennedy | 20 |
| Claire Goose | Jane Kennedy | 20 |
| Ivan Kaye | Mick Sturrock | 20 |
| Matt Bardock | DS Davey Higgins | 20 |
| Grace Hogg-Robinson | Beth Kennedy | 20 |
| Stuart Davidson | Private Ambulanceman | 2 |
| David Schofield | Ben Arnold | 1 |
| Ramon Tikaram | Don Shapur | 1 |
| Nick Brimble | Bob Fountain | 1 |
| Leon Ockenden | Danny Ball | 1 |
| Francis Magee | George James | 1 |
| Alex Ferns | Nolan Prince | 1 |
| Paul Copley | John Roxwell | 1 |
| David Sterne | John 'Blackbeard' Fraser | 1 |
| Susan Vidler | Antonia Foxby | 1 |
| David Westhead | Grantham Naseby | 1 |
| Andrew Havill | Edward Sidwell | 1 |
| Lucy Phelps | Gemma Duffy | 1 |
| Robin Laing | Eddie Landman | 1 |
| Richard Huw | Peter Walker | 1 |
| Maya Gerber | Lily Sidwell | 1 |
| Simon Armstrong | Errol Prowse | 1 |
| Phoebe Thomas | Dora Horton | 1 |
| Alan Williams | Keegan Brubaker | 1 |
| Stuart Davidson | Salsa Dancer | 1 |
| Stuart Davidson | Coastguard Rescue Officer | 1 |
| Alice Henley | Lucy Everidge | 1 |
| Ronan Vibert | Gavin Drake | 1 |
| Matthew Marsh | Sidney Sutton | 1 |
| Christopher Villiers | Tim Morris | 1 |
| Michael Culkin | Charles Gower | 1 |
| Florence Hall | Abby Naseby | 1 |
| Stephen Marcus | Gobby Mitchell | 1 |
| Claire Price | Joy Bradshaw | 1 |
| Rupert Procter | John Holland | 1 |
| Kate Miles | Cath Lowe | 1 |
| Georgia Henshaw | Amelia Prowse | 1 |
| James Weber Brown | Brian 'Digger' Digsby | 1 |
| Nigel Betts | Brian Teddern | 1 |
| Adie Allen | Karen Shaw | 1 |
| Vincenzo Nicoli | Tam Bryant | 1 |
| Joe Dixon | Samuel Mansfield | 1 |
| Sandra Voe | Peggy Winterson | 1 |
| Cassie Clare | Young Helen | 1 |
| Nicola Duffett | Amy Penketh | 1 |
| Andrew Whipp | Phillip Bailey | 1 |
| Gerald Kyd | Prof. Tal Greening | 1 |
| James Barriscale | Dick Hamilton | 1 |
| Rupert Lazarus | Anthony 'Stix' King | 1 |
| Emma Stansfield | Ruby Hamilton | 1 |
| Timothy Carlton | Donald Sidwell | 1 |
| Robert Morgan | Joseph Gravelle | 1 |
| Peter Gunn | Robert Talbot | 1 |
| Charles Babalola | Ian Igby | 1 |
| Simon Meacock | John Kernan | 1 |
| Amy Marston | Olivia Sidwell | 1 |
| Percelle Ascott | Jake Taylor | 1 |
| Macy Nyman | Ellie Patterson | 1 |
| Hazel Ellerby | Rose Porter | 1 |
| Daisy Beaumont | Anna Daniels | 1 |
| Alun Raglan | Terence Brooks | 1 |
| Katy Brand | Debs Luscombe | 1 |
| Sophie Duval | May Kernan | 1 |
| Naomi Ryan | Andrea Matteo | 1 |
| Tilly Blackwood | Una Drake | 1 |
| Chris Larkin | Oliver Foxby | 1 |
| Dean Williamson | Phil Tate | 1 |
| Suzette Llewellyn | Helen Boyd | 1 |
| Tupele Dorgu | Lori Fletcher | 1 |
| James Redmond | Dean Lowe | 1 |
| Alex Felton | Michael Larkin | 1 |
| Susy Kane | Claire Bryant | 1 |
| Heather Peace | Chrissy Woodward | 1 |
| Alexandra Evans | Young Antonia | 1 |
| Imogen Waterhouse | Sophie Bailey | 1 |