| Name | Character | Episodes |
|---|---|---|
| Kevin James | Kevin Gable | 48 |
| Ryan Cartwright | Chale | 48 |
| Taylor Spreitler | Kendra Gable | 48 |
| Gary Valentine | Kyle | 48 |
| Leonard Earl Howze | Goody | 48 |
| Leah Remini | Vanessa Cellucci | 26 |
| Erinn Hayes | Donna Gable | 24 |
| Mary-Charles Jones | Sara Gable | 24 |
| James DiGiacomo | Jack Gable | 24 |
| Florencia Lozano | Wendy | 2 |
| Adam Sandler | Jimmy (Kevin's former partner) | 1 |
| Harry Connick Jr. | Harry Connick Jr. | 1 |
| Chazz Palminteri | Vincent Cellucci | 1 |
| Bas Rutten | Rootger | 1 |
| Billy Joel | Billy Joel | 1 |
| Austyn Johnson | Jill | 1 |
| Loni Love | Yvette | 1 |
| Ali Landry | Lisa | 1 |
| Pete Correale | Larry | 1 |
| Pete Correale | Larry the Funky Dragon | 1 |