| Name | Character | Episodes |
|---|---|---|
| Joelle Carter | Laura Nagel | 13 |
| Monica Barbaro | Anna Valdez | 13 |
| Carl Weathers | Mark Jefferies | 13 |
| Jon Seda | Antonio Dawson | 13 |
| Philip Winchester | Peter Stone | 13 |
| Sal Velez Jr. | 2 | |
| Tim Kang | Steve Kim | 1 |
| Taylor Kinney | Kelly Severide | 1 |
| Richard Schiff | Frank Linden | 1 |
| Elias Koteas | Alvin Olinsky | 1 |
| Jason Beghe | Hank Voight | 1 |
| Eamonn Walker | Wallace Boden | 1 |
| Bradley Whitford | Albert Forest | 1 |
| Dylan Walsh | Ken Banks | 1 |
| Sophia Bush | Erin Lindsay | 1 |
| Kara Killmer | Sylvie Brett | 1 |
| Stacey Farber | Kerry Schmidt | 1 |
| Andrew Rothenberg | Creary's Lawyer | 1 |
| Faith Prince | Holly Washington | 1 |
| Gary Basaraba | William O'Boyle | 1 |
| Anna Friedman | Bethany Pierson | 1 |
| Josh Cooke | Ted Reynolds | 1 |
| Tom Guiry | Eric Cates | 1 |
| Lizzy DeClement | Caitlin | 1 |
| Chris Payne Gilbert | Professor Hall | 1 |
| Austin Lysy | Attorney Fetzer | 1 |
| Michael Aaron Milligan | Russell Evans | 1 |
| Emma Duncan | Sarah Wheeler | 1 |
| Julie Lauren | Mrs. Oates | 1 |
| James Vincent Meredith | Trial Judge | 1 |
| Karin Anglin | Alexa Grant | 1 |
| Emily Bennett | Corra | 1 |
| Torey Adkins | Otto | 1 |
| Maura Kidwell | Lizzie | 1 |