| Name | Character | Episodes |
|---|---|---|
| Lauren Lapkus | Jess | 24 |
| Artie Lange | Artie Lange | 24 |
| Pete Holmes | Pete | 24 |
| George Basil | Leif | 24 |
| T.J. Miller | T.J. Miller | 8 |
| Zach Cherry | Chicken Wing Man | 5 |
| Madeline Wise | Kat | 5 |
| John Mulaney | John Mulaney | 2 |
| Ray Romano | 1 | |
| Zach Cherry | Kevin woods | 1 |
| Dave Attell | 1 | |
| Jaboukie Young-White | 1 | |
| Jermaine Fowler | Russel | 1 |
| Audrie Neenan | Rita Holmes | 1 |
| Aparna Nancherla | 1 | |
| Marissa Jaret Winokur | 1 | |
| Elon Gold | 1 | |
| Seth Meyers | 1 | |
| Colin Quinn | 1 | |
| Kate Avallone | Maureen | 1 |
| Wayne Federman | 1 | |
| Emo Philips | 1 | |
| Greg Fitzsimmons | 1 | |
| Annie Pisapia | Audience member | 1 |
| Jessica Kirson | 1 | |
| Julia Shiplett | Julia | 1 |
| Ross Bryant | Gavin | 1 |