| Name | Character | Episodes |
|---|---|---|
| Lauren Tom | Celia Mack | 57 |
| Peyton Elizabeth Lee | Andi Mack | 57 |
| Asher Angel | Jonah Beck | 57 |
| Stoney Westmoreland | Ham Mack | 57 |
| Lilan Bowden | Bex Mack | 57 |
| Joshua Rush | Cyrus Goodman | 57 |
| Sofia Wylie | Buffy Driscoll | 57 |
| Luke Mullen | TJ | 18 |
| Garren Stitt | Marty | 13 |
| Anson Bagley | Gus | 7 |
| Emily Skinner | Amber | 5 |
| Trent Garrett | Bowie Quinn | 3 |
| Millicent Simmonds | Libby | 2 |
| Shelby Simmons | Natalie | 1 |
| Timothy Hornor | Todd | 1 |
| Peggy Blow | Madame Le Doux | 1 |
| Parker Queenan | Reed | 1 |
| Danny Jacobs | Norman Goodman | 1 |
| Jackie Joyner | Leslie Goodman | 1 |
| Roni Geva | Mrs. Mendenhall | 1 |