| Name | Character | Episodes |
|---|---|---|
| Hank Azaria | Jim Brockmire | 32 |
| Amanda Peet | Jules James | 20 |
| Tyrel Jackson Williams | Charles | 20 |
| Hemky Madera | Pedro Uribe | 10 |
| Katie Finneran | Lucy Brockmire | 9 |
| J.K. Simmons | Matt "The Bat" Hardesty | 8 |
| Tawny Newsome | Gabby Taylor | 8 |
| Reina Hardesty | Beth | 8 |
| Richard Kind | Gus Barton | 6 |
| Victoria Blade | Limòn | 6 |
| Utkarsh Ambudkar | Raj | 5 |
| Ryan Lee | John Elton | 5 |
| Molly Ephraim | Bartender | 5 |
| Toby Huss | Johnny the Hat | 5 |
| Steve Coulter | Coach Pom Pom | 5 |
| Joe Buck | Joe Buck | 5 |
| Martha Plimpton | Shirley | 4 |
| Dreama Walker | Whitney | 4 |
| Christine Woods | Maggie Nickols | 4 |
| David Walton | Gary | 4 |
| Becky Ann Baker | Jean Brockmire Glasscock | 4 |
| Jay DeVon Johnson | Moderator | 4 |
| Ego Nwodim | Liz | 4 |
| Carrie Preston | Elle | 3 |
| Phil Reeves | Art Newlie | 3 |
| Brian F. Durkin | Robbie Butler | 3 |
| Ron Clinton Smith | Freddie | 3 |
| Adriyan Rae | Yvonne | 3 |
| John Ales | New York Yankees Owner | 2 |
| David Pressman | Orion | 2 |
| Quinn Cooke | Denise | 2 |
| Andrew Hill Newman | Dr. Barrett | 2 |
| Dan Patrick | Dan Patrick | 2 |
| Bob Costas | Bob Costas | 2 |
| Tracey Bonner | Cassie | 2 |
| Christian Robinson | Dave | 2 |
| Drew Starkey | Brad Christie | 1 |
| David Sullivan | Rusty | 1 |
| Dan Castellaneta | Duke Yipkowski (voice) | 1 |
| Clifton Powell | Charles Sr. | 1 |
| Ross Marquand | Brockmire's Father | 1 |
| Lawrence Pressman | 1 | |
| Michael Bunin | Leslie | 1 |
| Lindsay Ayliffe | Minister | 1 |
| Linda Lavin | Lorraine | 1 |
| Adam Drescher | Stadium Manager | 1 |
| Paul F. Tompkins | Harold K. Finnegan | 1 |
| J. LaRose | Chief Sango Whitehorse | 1 |
| Selena Anduze | Doctor #2 | 1 |
| Vince Pisani | Male Brock-Head | 1 |
| Kimrie Lewis | Bobbi | 1 |
| Victoria Blade | Debbie / Limòn | 1 |
| Valerie Jane Parker | Groupie | 1 |
| Suehyla El-Attar | Kansas City Royals Staff Member | 1 |
| Ron Perkins | Abortion Doctor | 1 |
| Rebecca Koon | Carol | 1 |
| Valerie Azlynn | Janet | 1 |
| Keisuke Hoashi | Translator | 1 |
| Matt Levin | Man | 1 |
| Andrew Hill Newman | 1 | |
| Aina Dumlao | Diwata Cruz | 1 |
| Angela Relucio | Floribeth's Aunt | 1 |
| Lauren Halperin | Receptionist | 1 |
| David Silverman | Dylan's Dad | 1 |
| Joshua Hoover | Fatty Bombalatty | 1 |
| Lynne Ashe | Human Resources Manager | 1 |
| Joe Knezevich | Greg | 1 |
| Adelle Drahos | Podcast Superfan | 1 |
| George Brett | George Brett | 1 |
| Ted Huckabee | Leland | 1 |
| Sydney Wease | Mascot | 1 |
| Robert Tinsley | Oakland A's Baseball Player (uncredited) | 1 |
| Hakim Callender | Damon | 1 |
| Christian Robinson | Dave (uncredited) | 1 |
| Al Mitchell | Umpire | 1 |
| Jef Holbrook | Nephew Jim | 1 |