| Name | Character | Episodes |
|---|---|---|
| Wendell Pierce | Wiilbur Orwell | 2 |
| Paula Jai Parker | Patty Orwell | 2 |
| Jesse Plemons | Lemmon | 1 |
| Pablo Schreiber | Mattingley | 1 |
| Anna Kendrick | Shelby Johnson | 1 |
| Eric Roberts | Harry Siegel | 1 |
| Doug Jones | Grady Edlund | 1 |
| Brandon Routh | Bobby | 1 |
| Mark Pellegrino | Mr. Drake | 1 |
| Jessica Parker Kennedy | Becca | 1 |
| Ethan Embry | Chance Miller | 1 |
| John Billingsley | Phil | 1 |
| Gordon Tootoosis | Eddie Bear | 1 |
| Campbell Lane | Thug | 1 |
| Sarah Deakins | Kate | 1 |
| James Roday Rodriguez | Carlos the Groom | 1 |
| Molly Hagan | Elena Edlund | 1 |
| Martin Donovan | Officer Dan Johnson | 1 |
| Mircea Monroe | Virginia | 1 |
| Elisabeth Moss | Danny Bannerman | 1 |
| Eric Balfour | Maxwell | 1 |
| Cynthia Watros | Meredith Kane | 1 |
| Josie Davis | Kathy Mahoney | 1 |
| Camille Guaty | Karen / Zelda Flemming | 1 |
| Maggie Lawson | Samantha the Bride | 1 |
| Rachel Miner | Chelsea | 1 |
| Christine Chatelain | Jackie | 1 |
| Liam James | Young Harry | 1 |
| Jack Noseworthy | Rory Bemell | 1 |
| Zulay Henao | Christie | 1 |
| Niall Matter | Eddie | 1 |
| Marshall Bell | Carlos' Uncle Bob | 1 |
| Briana Evigan | Helen | 1 |
| Johnathon Schaech | Brian | 1 |
| Brett Dier | Derek Edlund | 1 |
| Lawrence Gilliard Jr. | James | 1 |
| Cory Monteith | James | 1 |
| George Buza | Crane Dougdale | 1 |
| Shiri Appleby | Tracy | 1 |
| Stephen Lobo | John Amir | 1 |
| William B. Davis | Father Chris | 1 |
| Clifton Collins Jr. | Richard 'Family Man' Brautigan | 1 |
| Russell Hornsby | Sergeant Wiliams | 1 |
| Aaron Stanford | Stephan | 1 |
| Barbara Tyson | Candace | 1 |
| Eric Keenleyside | George Clayton | 1 |
| Victoria Pratt | Robbie Collins | 1 |
| Fulvio Cecere | Det. Marvin Deane | 1 |
| John Pyper-Ferguson | Rowdy Edlund | 1 |
| Nathaniel Arcand | First Victim | 1 |
| Brooklyn Sudano | Arlene | 1 |
| J. LaRose | Thug | 1 |
| Ashley Scott | Lisa | 1 |
| Vondie Curtis-Hall | Walter Markham | 1 |
| Christie Laing | Kelly | 1 |
| Stephen Lee | Marty Steinwitz | 1 |
| Sophie Monk | Virginia | 1 |
| Gerard Plunkett | Dr. Wolfram | 1 |
| Colin Ferguson | Dennis Mahoney | 1 |
| Brent Stait | Deputy / Guard Toomey | 1 |
| Christopher Redman | Forest J. Caldwell | 1 |
| Charlie Hofheimer | Scott | 1 |
| Michael St. John Smith | Sheriff Weller | 1 |
| Issei Sagawa | Self | 1 |
| Ellen Ewusie | Walter's Wife | 1 |
| Walter Phelan | The Creature | 1 |
| Tom Carey | Simmons | 1 |
| Gig Morton | Sean Mahoney | 1 |
| Jeffrey Pierce | Point | 1 |
| Stephen R. Hart | Duane 'Eater' Mellor | 1 |
| Cole Heppell | Tim Edlund | 1 |
| Julian Christopher | Doctor | 1 |
| Alexandra Fatovich | Merly | 1 |
| Mark McCracken | Michael the Werewolf | 1 |
| Reamonn Joshee | Navarro | 1 |
| Melanie Nicholls-King | Anita | 1 |
| Sonja Bennett | Ruthie | 1 |
| Stephen Martines | Diego | 1 |
| Kailin See | Mikayla Kumpula | 1 |