| Name | Character | Episodes |
|---|---|---|
| Keegan-Michael Key | Self | 14 |
| Laraine Newman | Self | 14 |
| Rob Reiner | Self | 14 |
| Conan O'Brien | Self | 14 |
| Adam McKay | Self | 14 |
| Carol Burnett | Self | 14 |
| Kevin Smith | Self | 14 |
| Patton Oswalt | Self | 14 |
| Carl Reiner | Self | 14 |
| Jimmy Kimmel | Self | 14 |
| Bobcat Goldthwait | Self | 14 |
| Arsenio Hall | Self | 14 |
| Harry Shearer | Self | 14 |
| Judd Apatow | Self | 14 |
| Robert Klein | Self | 14 |
| Maria Bamford | Self | 14 |
| Lewis Black | Self | 14 |
| Gilbert Gottfried | Self | 14 |
| Ali Wong | Self | 14 |
| Larry David | Self | 14 |
| Marc Maron | Self | 14 |
| Craig Ferguson | Self | 14 |
| Betty White | Self | 14 |
| Sarah Silverman | Self | 14 |
| David Zucker | Self | 14 |
| Larry Charles | Self | 14 |
| 'Weird Al' Yankovic | Self | 14 |
| Jim Jefferies | Self | 14 |
| Samantha Bee | Self | 14 |
| Robert B. Weide | Self | 14 |
| W. Kamau Bell | Self | 14 |
| Neal Brennan | Self | 14 |
| Rain Pryor | Self | 14 |
| Anne Beatts | Self | 14 |
| Kent Alterman | Self | 14 |
| Al Franken | Self | 14 |
| Jerry Zucker | Self | 14 |
| Todd Boyd | Self | 14 |
| Jeff Ross | Self | 8 |
| Larry David | Self - Creator, Seinfeld | 6 |