| Name | Character | Episodes |
|---|---|---|
| Regina King | Latrice Butler | 10 |
| Nadia Alexander | Nadine | 10 |
| Michael Mosley | Joe 'Fish' Rinaldi | 10 |
| Beau Knapp | Peter Jablonski | 10 |
| David Lyons | Mike Diangelo | 10 |
| Raúl Castillo | Felix Osorio | 10 |
| Russell Hornsby | Isaiah Butler | 10 |
| Clare-Hope Ashitey | KJ Harper | 10 |
| Zackary Momoh | Seth Butler | 10 |
| Patrick Murney | Manny Wilcox | 10 |
| Jeremy Davidson | James Connelly | 8 |
| Adriana DeMeo | Teresa | 8 |
| Mustafa Speaks | Vontrell 'Messiah' Odoms | 7 |
| Lesli Margherita | Crystal DiAngelo | 5 |
| David Zayas | Medina | 3 |
| Gretchen Mol | Sam Hennessy | 3 |
| Fredric Lehne | Peter Jablonski, Sr. | 3 |
| Sprague Grayden | Alison | 3 |
| Ron Canada | Pastor Adler | 3 |
| Robert Turano | Howard | 3 |
| Socorro Santiago | Esmeralda | 3 |
| Jorge Cordova | Luis Carillo | 3 |
| Melanie Nicholls-King | Marcelle | 3 |
| James Chen | Franklin Lee | 2 |
| Brian O'Neill | Judge Robert P. Dolan | 2 |
| Gamze Ceylan | Dr. Sayegh | 2 |
| Bill Buell | Mac Dorsey | 2 |
| Heather Simms | Elle | 2 |
| Vandit Bhatt | Male Jogger | 1 |