| Name | Character | Episodes |
|---|---|---|
| Fareed Zakaria | Self - Host | 12 |
| Anderson Cooper | Self - Host | 9 |
| Sanjay Gupta | Self - Host | 7 |
| Anthony Fauci | Self | 2 |
| Ken Burns | Self | 1 |
| Britney Spears | Self - Archive Footage | 1 |
| Al Gore | Self | 1 |
| Anderson Cooper | Self - Anchor | 1 |
| Gilbert Gottfried | Self | 1 |
| Greta Thunberg | Self | 1 |
| Cory Booker | Self | 1 |
| Billy West | Self | 1 |
| Kamala Harris | Self | 1 |
| Judy Gold | Self | 1 |
| Rosie O'Donnell | Self | 1 |
| Gavin Newsom | Self | 1 |
| Wolf Blitzer | Self - Anchor | 1 |
| Wolf Blitzer | Self - Host | 1 |
| Helen Hong | Self | 1 |
| Alex E. Jones | Self | 1 |
| Ronan Farrow | Self | 1 |
| Jon Meacham | Self | 1 |
| Thomas L. Friedman | Self | 1 |
| Van Jones | Self - Host | 1 |
| Dana Bash | Self - Host | 1 |
| Richard Spencer | Self | 1 |
| Fareed Zakaria | Narrator | 1 |
| Owen Smith | Self | 1 |
| Lisa Pine | Self | 1 |